Fig. 5

Alignment of members of glucose transporters class I. Class I glucose transporters amino acid sequences from human (GLUT1-4 and GLUT-14) and S. mansoni (SGTP1, SGTP2, SGTP3 and SGTP4) were aligned using MAFFT. Relevant motifs among human class I/II glucose transporters and S. mansoni are highlighted. Annotation of relevant motifs was done using previous reports [21, 25, 26]. The 12 transmembrane (TM) topologies, predicted using TMHMM Server v. 2.0 [27], are indicated. The positions of the invariant residues of XylE (green) and GLUT1 (red) are marked. The substitution of Asn(N)88 by Lys(K)88 found in the genome for SGTP2 is boxed (orange). The number of amino acid insertions that resulted from the alignment are shown in brackets