Fig. 6

XylE and GLUT1 compared to the tertiary predicted structures of S. mansoni glucose transporters. Panel a (from left to right) shows the crystal structures of glucose transporters GLUT1 of H. sapiens [PDB: 4PYP] and XylE of E. coli [PDB: 4GBZ]. The transmembrane (TM) α-helices (middle) are numbered (1–12) accordingly (IC = intracellular) with the α-carbon backbone structural alignment of both crystal structures (GLUT1 = red and XylE = green; far right). Panel b shows the tertiary predicted structures of S. mansoni glucose transporters (left) with the structural alignment (right) of SGTP1 (blue) and SGTP4 (brown) with XylE of E. coli (green), and SGTP2 (magenta) and SGTP3 (cyan) with GLUT1 of H. sapiens (red). Structures are color-coded from the amino-terminus (N-ter; red) to the carboxyl-terminus (C-ter; blue). The structural alignment of the α-carbon backbone was performed using the default tool of Schrodinger’s Maestro program