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Table 1 Phenotypes of 10 weeks old males and females of reciprocal crosses between BFMI and B6N with and without cross-fostering on high fat diet

From: The direction of cross affects obesity after puberty in male but not female offspring

Phenotypes1 F1(BFMI x B6N) F1(B6N x BFMI) p-Value for direction-of-cross effect
BFMI father (patBFMI) BFMI mother (matBFMI)
  Males Females Males Females Males Females
Maternal fostering
 Body mass (g) 34.23 (3.26) 26.16 (2.02) 36.82 (3.96) 25.27 (2.06) n.s. n.s.
 Fat mass (g) 3.86 (1.49) 3.34 (1.01) 7.06 (2.56) 3.44 (1.04) 0.0037 n.s.
 Lean mass (g) 27.54 (2.06) 20.45 (1.00) 26.93 (2.10) 19.68 (1.09) 0.0536 0.0855
 Fat / Lean mass ratio 0.14 (0.05) 0.16 (0.04) 0.26 (0.08) 0.17 (0.05) 0.0009 n.s.
 Liver mass (g) 1.55 (0.23) 1.21 (0.10) 1.68 (0.18) 1.16 (0.12) n.s. n.s.
 Liver triglycerides/ protein (μg/μg) 0.45 (0.09) 0.47 (0.11) 0.59 (0.22) 0.45 (0.08) 0.0843 n.s.
 Blood glucose levels (mg/dl) 165.33 (27.20) 135.92 (12.22) 174.25 (23.80) 133.25 (10.71) n.s. n.s.
Cross-fostering
 Body mass (g) 34.27 (3.41) 25.96 (3.75) 35.63 (2.65) 24.36 (1.71) n.s. n.s.
 Fat mass (g) 4.06 (2.06) 3.45 (1.56) 5.54 (1.74) * 2.70 (0.99) 0.0142 n.s.
 Lean mass (g) 29.54 (1.84) ** 21.69 (3.06) 29.61 (1.68) ** 20.64 (1.19) ° n.s. n.s.
 Fat / Lean mass ratio 0.14 (0.06) 0.16 (0.07) 0.19 (0.06) ** 0.13 (0.04) ° 0.0067 n.s.
 Liver mass (g) 1.66 (0.21) 1.22 (0.23) 1.75 (0.15) 1.17 (0.13) n.s. n.s.
 Liver triglycerides/ protein (μg/μg) 0.15 (0.09)** 0.34 (0.17)° 0.21 (0.08)** 0.26 (0.13)** 0.0307 n.s.
 Blood glucose levels (mg/dl) 137.82 (19.07) ** 130.36 (13.13) 151.83 (22.7) * 139.29 (20.64) 0.0307 n.s.
  1. 1shown are means ± standard deviation after correction for litter size, except for blood glucose and liver triglycerides, which were not affected by the litter size. Asterisks additionally indicate significant effects of cross fostering on phenotypes comparing animals of the same direction of cross (patBFMI vs. cross-fostered patBFMI, matBFMI vs. cross-fostered matBFMI) (**p < 0.01, *p < 0.05, °p < 0.1)
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