Fig. 5

The seasonal miR-210 –mRNA regulatory network in HVC. a The expression fold changes of miR-210 mRNA that were differentially regulated and inversely correlated in at least one experimental group in which miR-210 was also differentially expressed (i.e. LD + T 7D, 21, or LDW) compared to SD. A p-value of <0.005 and fold change >1.5 at any time point were used as selection criteria for mRNAs presented in the heat map. b An interaction network of mRNAs that were differentially anti-expressed with a fold change > 1.5 and p < 0.005 (bright) or p < 0.05 (faded) from conditions in which miR-210 was also differentially expressed (i.e. fold change > –2.0). IPA network analyses revealed several key pathways were up-regulated in Area X during periods of volume expansion