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Table 3 Relative increase in mean estimated r 2 by reference sample size (MAF 0.5–1 %)

From: A new strategy for enhancing imputation quality of rare variants from next-generation sequencing data via combining SNP and exome chip data

Genotype panel 300 to 500 500 to 700 700 to 848
SNP chip only 9.27 % 4.90 % 2.09 %
Combined (SNP + exome chip) 8.18 % 4.46 % 1.74 %