Collaborative cross mice in a genetic association study reveal new candidate genes for bone microarchitecture

BMC Genomics

Table 2 Positions of QTLs associated with trabecular traits

QTL	Trait	Chr	logP	99th % threshold logP	Sig	H² _r	logP H² _r	50 % CI				90 % CI		95 % CI
								Simulation		Li (2011)
								Position	Width (Mb)	Position	Width (Mb)	Position	Width (Mb)	Position	Width (Mb)
Trl1	BV/TV	2.00	6.67	5.01	0.01	0.60	2.46	130.48-130.68	0.20	129.9-130.5	0.60	128.08-132.8	4.70	126.2-135.6	9.40
Trl2	BV/TV	2.00	6.31	5.01	0.01	0.67	3.37	121.9-122.2	0.30	119.6-123.4	3.80	121.7-122.4	0.70	115.6-124.9	9.30
Trl3	Tb.N	8.00	5.63	4.88	0.01	0.61	2.42	37.2-40.47	3.27	37.8-41.2	3.40	31.8-43.9	12.40	30.8-46.9	16.10
Trl4	Tb.Th	7.00	7.87	5.14	0.01	0.86	6.75	64.6-64.8	0.20	63.7-65.6	1.90	63.8-65.7	1.90	62.7-68.1	5.40
Trl5	Tb.Th	7.00	5.36	5.14	0.01	0.73	12.77	73.4-73.5	0.13	73.2-73.7	0.52	70.4-75.1	4.74	66.01-77.9	10.73
Trl6	Conn.D	14.00	6.36	5.17	0.01	0.66	12.77	69.8-79.74	9.94	70.7-79.2	8.50	66.7-77.2	10.62	64.7-77.1	13.50

Chr chromosome; logP = negative 10-base logarithm of P value; Sig = genome-wide significance level; 99th % threshold logP = threshold used to define cut-off for QTL peaks (Fig. 4); H_r ² = regional heritability. Positions and widths of the simulation-based 50, 90, and 95 % CIs are given, as well as 50 % CIs calculated after Li (2011). (See text.)

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