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Fig. 3 | BMC Genomics

Fig. 3

From: Similar striatal gene expression profiles in the striatum of the YAC128 and HdhQ150 mouse models of Huntington’s disease are not reflected in mutant Huntingtin inclusion prevalence

Fig. 3

Correlation of direction of expression changes in YAC128 striata, other mouse models of HD and human HD caudate. a shows the overlap of genes within the FDR adjusteddifferentially expressed genes from the YAC128 compared with the HdhQ150 mouse striata. In B and C frequency  represents the fraction of the top 200 HdhQ150 expression changes that map to a particular bin of ranked data (1000 genes per bin) in the other dataset, which is then split to concordant or discordant direction of expression change. A higher frequency of concordant (green) rather than discordant (red) in the first bins indicates a similarity between the YAC128 caudate and other model or human HD gene expression signature. b shows the comparison of YAC128 striatal gene expression with human HD brain regions [18] and the comparison with other mouse models and c shows the comparison at the same time points with the HdhQ150 striatal gene expression.

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BMC Genomics

ISSN: 1471-2164

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