Similar striatal gene expression profiles in the striatum of the YAC128 and HdhQ150 mouse models of Huntington’s disease are not reflected in mutant Huntingtin inclusion prevalence

Table 1 Pathways altered with age in mouse striatum in YAC128 mice

ID	GO term	p-value	FDR p	Count	Global
WT 6 - 12 m
GO:0006412	Translation	2.00E-05	0.043	39	317
HD 6 - 12 m
GO:0007155	Cell adhesion	3.03E-05	0.059	32	384
WT 12 - 18 m
GO:0007608	Sensory perception of smell	2.47E-21	2.07E-18	68	1098
GO:0007600	Sensory perception	1.80E-17	1.51E-14	70	1364
GO:0007186	G-protein coupled receptor protein signaling pathway	1.64E-16	1.37E-13	76	1657
GO:0050877	Neurological system process	1.17E-14	9.73E-12	72	1620
GO:0007165	Signal transduction	2.03E-09	1.69E-06	100	3381
GO:0019236	Response to pheromone	5.91E-05	0.049	9	100
HD 12 - 18 m
GO:0042391	Regulation of membrane potential	1.87E-07	0.001	32	105
GO:0055082	Cellular chemical homeostasis	2.69E-06	0.0081	50	221
GO:0048167	Regulation of synaptic plasticity	1.19E-05	0.0371	14	34
GO:0019226	Transmission of nerve impulse	1.37E-05	0.043	15	39
GO:0007155	Cell adhesion	1.77E-05	0.055	87	483

The probesets and genes that were significant over time are given in Table S1 and the full list of pathways in Table S2. Count is the total number of significantly differentially expressed probesets in the GO category and Global is the number of genes in that GO category.

ISSN: 1471-2164