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Table 1 Pathways altered with age in mouse striatum in YAC128 mice

From: Similar striatal gene expression profiles in the striatum of the YAC128 and HdhQ150 mouse models of Huntington’s disease are not reflected in mutant Huntingtin inclusion prevalence

ID GO term p-value FDR p Count Global
WT 6 - 12 m      
GO:0006412 Translation 2.00E-05 0.043 39 317
HD 6 - 12 m      
GO:0007155 Cell adhesion 3.03E-05 0.059 32 384
WT 12 - 18 m      
GO:0007608 Sensory perception of smell 2.47E-21 2.07E-18 68 1098
GO:0007600 Sensory perception 1.80E-17 1.51E-14 70 1364
GO:0007186 G-protein coupled receptor protein signaling pathway 1.64E-16 1.37E-13 76 1657
GO:0050877 Neurological system process 1.17E-14 9.73E-12 72 1620
GO:0007165 Signal transduction 2.03E-09 1.69E-06 100 3381
GO:0019236 Response to pheromone 5.91E-05 0.049 9 100
HD 12 - 18 m      
GO:0042391 Regulation of membrane potential 1.87E-07 0.001 32 105
GO:0055082 Cellular chemical homeostasis 2.69E-06 0.0081 50 221
GO:0048167 Regulation of synaptic plasticity 1.19E-05 0.0371 14 34
GO:0019226 Transmission of nerve impulse 1.37E-05 0.043 15 39
GO:0007155 Cell adhesion 1.77E-05 0.055 87 483
  1. The probesets and genes that were significant over time are given in Table S1 and the full list of pathways in Table S2. Count is the total number of significantly differentially expressed probesets in the GO category and Global is the number of genes in that GO category.