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Table 2 Probesets dysregulated between genotypes

From: Similar striatal gene expression profiles in the striatum of the YAC128 and HdhQ150 mouse models of Huntington’s disease are not reflected in mutant Huntingtin inclusion prevalence

Gene ID All 6 m 12 m 18 m
p-value log2FC AbsFC p-value log2FC AbsFC p-value log2FC AbsFC p-value log2FC AbsFC
Down in YAC128             
Phex 1.13E-05 −0.645 1.564 1.58E-05 −0.649 1.568 2.09E-01 −0.596 1.512 2.84E-02 −0.691 1.615
Gm501 5.08E-05 −0.494 1.408 7.75E-04 −0.374 1.296 8.17E-02 −0.575 1.490 3.91E-02 −0.532 1.446
Plk5 5.08E-05 −0.448 1.364 6.26E-04 −0.358 1.282 2.27E-01 −0.409 1.328 1.29E-02 −0.577 1.492
Galnt13 1.76E-04 −0.442 1.359 3.52E-04 −0.437 1.353 6.91E-01 −0.374 1.296 8.24E-02 −0.516 1.430
Actn2 1.96E-04 −0.765 1.699 1.60E-04 −0.760 1.694 9.21E-01 −0.591 1.506 3.76E-02 −0.944 1.924
Dgat2l6 1.96E-04 −0.311 1.240 2.30E-04 −0.290 1.223 1.00E + 00 −0.230 1.173 1.42E-02 −0.412 1.331
Sec14l3 2.30E-04 −0.413 1.332 2.84E-03 −0.306 1.236 2.09E-01 −0.444 1.360 4.76E-02 −0.490 1.405
Odf4 2.67E-04 −0.384 1.305 8.07E-04 −0.384 1.305 6.37E-01 −0.391 1.311 2.33E-01 −0.377 1.299
Ptprv 9.42E-04 −0.322 1.250 7.77E-03 −0.255 1.193 7.66E-01 −0.314 1.243 1.08E-01 −0.396 1.316
Ddit4l 1.53E-03 −0.407 1.326 1.71E-04 −0.432 1.349 3.78E-01 −0.430 1.348 2.57E-01 −0.359 1.282
Ryr1 1.80E-03 −0.577 1.492 7.51E-04 −0.507 1.421 8.22E-01 −0.464 1.379 2.73E-02 −0.760 1.694
Npl 2.05E-03 −0.277 1.212 4.42E-02 −0.166 1.122 4.02E-01 −0.319 1.247 1.14E-01 −0.348 1.273
Cdc2l6 2.16E-03 −0.278 1.213 3.58E-04 −0.312 1.241 9.98E-01 −0.262 1.199 2.96E-01 −0.260 1.198
Krt9 2.72E-03 −0.393 1.313 2.47E-02 −0.289 1.221 8.22E-01 −0.423 1.341 2.06E-01 −0.468 1.383
Hvcn1 2.72E-03 −0.229 1.172 1.49E-03 −0.232 1.174 1.00E + 00 −0.151 1.110 9.09E-02 −0.305 1.235
Aoah 4.47E-03 −0.197 1.146 1.33E-02 −0.158 1.116 1.00E + 00 −0.210 1.157 2.26E-01 −0.223 1.167
Bmp2 4.57E-03 −0.286 1.219 4.42E-03 −0.263 1.200 3.78E-01 −0.354 1.278 4.72E-01 −0.240 1.181
Clspn 5.34E-03 −0.355 1.279 7.12E-03 −0.271 1.207 6.68E-01 −0.360 1.284 9.09E-02 −0.435 1.352
Kcnk13 8.57E-03 −0.164 1.120 1.79E-02 −0.135 1.098 7.97E-01 −0.203 1.151 4.72E-01 −0.152 1.111
Glul (2 probes) 9.47E-03 −0.170 1.125 7.37E-03 −0.147 1.107 3.79E-01 −0.222 1.166 4.83E-01 −0.142 1.103
Pkp2 1.02E-02 −0.282 1.216 9.44E-04 −0.313 1.242 3.78E-01 −0.370 1.292 7.26E-01 −0.164 1.120
Oprk1 1.48E-02 −0.456 1.372 1.49E-02 −0.307 1.237 1.00E + 00 −0.333 1.260 1.29E-02 −0.728 1.656
Cnr1 1.48E-02 −0.452 1.368 1.49E-02 −0.369 1.291 1.00E + 00 −0.442 1.359 2.09E-01 −0.545 1.459
Gpr155 1.48E-02 −0.329 1.256 6.12E-04 −0.438 1.355 1.00E + 00 −0.243 1.184 5.06E-01 −0.305 1.235
Zfp180 1.55E-02 −0.216 1.161 9.49E-04 −0.256 1.194 1.00E + 00 −0.165 1.121 3.30E-01 −0.226 1.170
Vrk1 1.93E-02 −0.243 1.184 1.58E-02 −0.223 1.167 1.00E + 00 −0.189 1.140 2.49E-01 −0.317 1.245
Farp2 2.05E-02 −0.154 1.112 4.16E-02 −0.123 1.089 1.00E + 00 −0.133 1.097 2.70E-01 −0.204 1.152
Il33 2.10E-02 −0.398 1.318 3.32E-04 −0.358 1.282 8.17E-02 −0.471 1.386 1.38E-01 −0.365 1.288
Tspan2 2.17E-02 −0.327 1.255 1.07E-02 −0.277 1.212 6.81E-01 −0.356 1.280 2.81E-01 −0.349 1.274
Scn4b 2.20E-02 −0.537 1.451 1.81E-03 −0.628 1.545 1.00E + 00 −0.401 1.320 3.58E-01 −0.582 1.497
Sbsn 2.20E-02 −0.183 1.135 1.56E-02 −0.175 1.129 1.00E + 00 −0.150 1.109 3.30E-01 −0.223 1.168
Ube2cbp 2.20E-02 −0.156 1.114 1.02E-02 −0.159 1.116 1.00E + 00 −0.160 1.117 5.38E-01 −0.150 1.110
Ppp1r9b 2.20E-02 −0.148 1.108 9.75E-03 −0.145 1.106 1.00E + 00 −0.080 1.057 1.34E-01 −0.220 1.165
Fn3k 2.20E-02 −0.143 1.104 2.64E-02 −0.121 1.088 7.91E-01 −0.178 1.131 5.71E-01 −0.129 1.094
Gpx6 2.24E-02 −0.652 1.571 2.59E-01 −0.243 1.183 1.00E + 00 −0.519 1.433 2.73E-02 −1.195 2.289
Erbb2ip 2.24E-02 −0.205 1.153 5.15E-03 −0.209 1.156 9.68E-01 −0.236 1.178 5.71E-01 −0.172 1.126
Lrrk2 3.02E-02 −0.372 1.294 4.21E-03 −0.412 1.331 1.00E + 00 −0.273 1.208 3.39E-01 −0.430 1.347
Ppp1r9a 3.21E-02 −0.265 1.201 1.15E-02 −0.269 1.205 1.00E + 00 −0.187 1.139 2.96E-01 −0.338 1.264
Traip 3.82E-02 −0.256 1.195 7.04E-02 −0.171 1.125 1.00E + 00 −0.146 1.106 6.65E-02 −0.453 1.369
Slc1a2 4.13E-02 −0.141 1.103 3.27E-02 −0.126 1.091 1.00E + 00 −0.164 1.120 6.16E-01 −0.133 1.097
Bank1 4.21E-02 −0.240 1.181 2.04E-03 −0.291 1.223 1.00E + 00 −0.131 1.095 2.73E-01 −0.298 1.229
Rnf8 4.72E-02 −0.116 1.084 7.03E-03 −0.130 1.094 1.00E + 00 −0.070 1.050 3.30E-01 −0.147 1.107
Up in YAC 128             
Tmc3 1.30E-04 0.480 1.395 1.49E-04 0.374 1.296 2.27E-01 0.395 1.315 6.46E-04 0.672 1.593
Polr2a 2.30E-04 0.288 1.221 2.54E-03 0.230 1.173 6.81E-01 0.279 1.214 6.12E-02 0.354 1.278
Il17rb 9.51E-04 0.238 1.179 2.36E-05 0.270 1.206 9.04E-01 0.198 1.147 9.09E-02 0.246 1.186
Fat1 1.27E-03 0.277 1.212 6.20E-04 0.290 1.223 1.00E + 00 0.276 1.211 2.70E-01 0.265 1.201
Ppia (6 probes) 2.16E-03 0.188 1.139 1.65E-03 0.189 1.140 1.00E + 00 0.151 1.110 1.45E-01 0.224 1.168
Lrrn3 2.16E-03 0.280 1.214 7.46E-04 0.310 1.240 9.98E-01 0.290 1.223 4.51E-01 0.240 1.181
Chdh 4.11E-03 0.181 1.134 9.58E-03 0.160 1.117 1.00E + 00 0.177 1.130 2.60E-01 0.207 1.154
Acy3 4.57E-03 0.292 1.224 2.42E-02 0.171 1.126 2.57E-01 0.322 1.250 4.05E-02 0.383 1.304
Stat1 7.72E-03 0.203 1.151 4.04E-02 0.140 1.102 1.00E + 00 0.227 1.170 2.26E-01 0.244 1.184
Smoc1 1.61E-02 0.265 1.202 3.00E-02 0.190 1.141 1.00E + 00 0.257 1.195 1.38E-01 0.348 1.273
Rnf122 2.05E-02 0.186 1.138 9.00E-02 0.112 1.081 1.00E + 00 0.181 1.134 1.45E-01 0.264 1.201
Cited2 2.05E-02 0.246 1.186 1.89E-02 0.225 1.169 1.00E + 00 0.225 1.169 3.64E-01 0.288 1.221
Enpp6 2.05E-02 0.365 1.288 2.66E-02 0.257 1.195 1.00E + 00 0.335 1.261 9.29E-02 0.504 1.418
Spata5 2.29E-02 0.177 1.131 4.76E-03 0.202 1.150 1.00E + 00 0.183 1.135 6.69E-01 0.146 1.107
Htr2a 2.58E-02 0.362 1.285 4.80E-02 0.284 1.218 7.53E-01 0.469 1.384 6.08E-01 0.334 1.260
Arsb (2 probes) 2.61E-02 0.176 1.130 1.13E-02 0.180 1.133 1.00E + 00 0.104 1.075 2.33E-01 0.244 1.185
Grhpr 3.21E-02 0.188 1.139 4.07E-02 0.144 1.105 1.00E + 00 0.152 1.111 1.65E-01 0.270 1.205
Zfp488 3.55E-02 0.236 1.178 5.66E-01 0.040 1.028 2.27E-01 0.331 1.257 7.49E-02 0.338 1.264
Pla2g4a 3.55E-02 0.253 1.191 3.29E-02 0.172 1.127 1.00E + 00 0.251 1.190 1.17E-01 0.335 1.261
Pou6f2 4.02E-02 0.170 1.125 5.31E-02 0.141 1.103 1.00E + 00 0.152 1.111 3.87E-01 0.218 1.163
Eya1 4.21E-02 0.246 1.186 2.01E-02 0.223 1.167 1.00E + 00 0.233 1.175 3.90E-01 0.281 1.215
Ifit1 4.21E-02 0.383 1.304 8.37E-03 0.380 1.301 1.00E + 00 0.388 1.308 4.67E-01 0.382 1.303
Nfe2l3 4.27E-02 0.169 1.125 4.26E-02 0.109 1.079 1.00E + 00 0.067 1.048 1.29E-02 0.332 1.258
Plekhh2 4.72E-02 0.200 1.148 1.95E-05 0.284 1.218 1.00E + 00 0.144 1.105 3.90E-01 0.171 1.126
Mobkl2b 4.82E-02 0.225 1.169 2.45E-02 0.171 1.126 1.00E + 00 0.254 1.192 2.73E-01 0.251 1.190
  1. Probsets annotated to genes with a significant difference (FDR p < 0.05) between the two genotypes are given. Each gene corresponds to a single probeset unless indicated otherwise, the probeset of lowest p-value for all ages has been quoted in such cases. FC = fold change, AbsFC = absolute fold change.