Skip to main content

Table 2 Probesets dysregulated between genotypes

From: Similar striatal gene expression profiles in the striatum of the YAC128 and HdhQ150 mouse models of Huntington’s disease are not reflected in mutant Huntingtin inclusion prevalence

Gene ID

All

6 m

12 m

18 m

p-value

log2FC

AbsFC

p-value

log2FC

AbsFC

p-value

log2FC

AbsFC

p-value

log2FC

AbsFC

Down in YAC128

            

Phex

1.13E-05

−0.645

1.564

1.58E-05

−0.649

1.568

2.09E-01

−0.596

1.512

2.84E-02

−0.691

1.615

Gm501

5.08E-05

−0.494

1.408

7.75E-04

−0.374

1.296

8.17E-02

−0.575

1.490

3.91E-02

−0.532

1.446

Plk5

5.08E-05

−0.448

1.364

6.26E-04

−0.358

1.282

2.27E-01

−0.409

1.328

1.29E-02

−0.577

1.492

Galnt13

1.76E-04

−0.442

1.359

3.52E-04

−0.437

1.353

6.91E-01

−0.374

1.296

8.24E-02

−0.516

1.430

Actn2

1.96E-04

−0.765

1.699

1.60E-04

−0.760

1.694

9.21E-01

−0.591

1.506

3.76E-02

−0.944

1.924

Dgat2l6

1.96E-04

−0.311

1.240

2.30E-04

−0.290

1.223

1.00E + 00

−0.230

1.173

1.42E-02

−0.412

1.331

Sec14l3

2.30E-04

−0.413

1.332

2.84E-03

−0.306

1.236

2.09E-01

−0.444

1.360

4.76E-02

−0.490

1.405

Odf4

2.67E-04

−0.384

1.305

8.07E-04

−0.384

1.305

6.37E-01

−0.391

1.311

2.33E-01

−0.377

1.299

Ptprv

9.42E-04

−0.322

1.250

7.77E-03

−0.255

1.193

7.66E-01

−0.314

1.243

1.08E-01

−0.396

1.316

Ddit4l

1.53E-03

−0.407

1.326

1.71E-04

−0.432

1.349

3.78E-01

−0.430

1.348

2.57E-01

−0.359

1.282

Ryr1

1.80E-03

−0.577

1.492

7.51E-04

−0.507

1.421

8.22E-01

−0.464

1.379

2.73E-02

−0.760

1.694

Npl

2.05E-03

−0.277

1.212

4.42E-02

−0.166

1.122

4.02E-01

−0.319

1.247

1.14E-01

−0.348

1.273

Cdc2l6

2.16E-03

−0.278

1.213

3.58E-04

−0.312

1.241

9.98E-01

−0.262

1.199

2.96E-01

−0.260

1.198

Krt9

2.72E-03

−0.393

1.313

2.47E-02

−0.289

1.221

8.22E-01

−0.423

1.341

2.06E-01

−0.468

1.383

Hvcn1

2.72E-03

−0.229

1.172

1.49E-03

−0.232

1.174

1.00E + 00

−0.151

1.110

9.09E-02

−0.305

1.235

Aoah

4.47E-03

−0.197

1.146

1.33E-02

−0.158

1.116

1.00E + 00

−0.210

1.157

2.26E-01

−0.223

1.167

Bmp2

4.57E-03

−0.286

1.219

4.42E-03

−0.263

1.200

3.78E-01

−0.354

1.278

4.72E-01

−0.240

1.181

Clspn

5.34E-03

−0.355

1.279

7.12E-03

−0.271

1.207

6.68E-01

−0.360

1.284

9.09E-02

−0.435

1.352

Kcnk13

8.57E-03

−0.164

1.120

1.79E-02

−0.135

1.098

7.97E-01

−0.203

1.151

4.72E-01

−0.152

1.111

Glul (2 probes)

9.47E-03

−0.170

1.125

7.37E-03

−0.147

1.107

3.79E-01

−0.222

1.166

4.83E-01

−0.142

1.103

Pkp2

1.02E-02

−0.282

1.216

9.44E-04

−0.313

1.242

3.78E-01

−0.370

1.292

7.26E-01

−0.164

1.120

Oprk1

1.48E-02

−0.456

1.372

1.49E-02

−0.307

1.237

1.00E + 00

−0.333

1.260

1.29E-02

−0.728

1.656

Cnr1

1.48E-02

−0.452

1.368

1.49E-02

−0.369

1.291

1.00E + 00

−0.442

1.359

2.09E-01

−0.545

1.459

Gpr155

1.48E-02

−0.329

1.256

6.12E-04

−0.438

1.355

1.00E + 00

−0.243

1.184

5.06E-01

−0.305

1.235

Zfp180

1.55E-02

−0.216

1.161

9.49E-04

−0.256

1.194

1.00E + 00

−0.165

1.121

3.30E-01

−0.226

1.170

Vrk1

1.93E-02

−0.243

1.184

1.58E-02

−0.223

1.167

1.00E + 00

−0.189

1.140

2.49E-01

−0.317

1.245

Farp2

2.05E-02

−0.154

1.112

4.16E-02

−0.123

1.089

1.00E + 00

−0.133

1.097

2.70E-01

−0.204

1.152

Il33

2.10E-02

−0.398

1.318

3.32E-04

−0.358

1.282

8.17E-02

−0.471

1.386

1.38E-01

−0.365

1.288

Tspan2

2.17E-02

−0.327

1.255

1.07E-02

−0.277

1.212

6.81E-01

−0.356

1.280

2.81E-01

−0.349

1.274

Scn4b

2.20E-02

−0.537

1.451

1.81E-03

−0.628

1.545

1.00E + 00

−0.401

1.320

3.58E-01

−0.582

1.497

Sbsn

2.20E-02

−0.183

1.135

1.56E-02

−0.175

1.129

1.00E + 00

−0.150

1.109

3.30E-01

−0.223

1.168

Ube2cbp

2.20E-02

−0.156

1.114

1.02E-02

−0.159

1.116

1.00E + 00

−0.160

1.117

5.38E-01

−0.150

1.110

Ppp1r9b

2.20E-02

−0.148

1.108

9.75E-03

−0.145

1.106

1.00E + 00

−0.080

1.057

1.34E-01

−0.220

1.165

Fn3k

2.20E-02

−0.143

1.104

2.64E-02

−0.121

1.088

7.91E-01

−0.178

1.131

5.71E-01

−0.129

1.094

Gpx6

2.24E-02

−0.652

1.571

2.59E-01

−0.243

1.183

1.00E + 00

−0.519

1.433

2.73E-02

−1.195

2.289

Erbb2ip

2.24E-02

−0.205

1.153

5.15E-03

−0.209

1.156

9.68E-01

−0.236

1.178

5.71E-01

−0.172

1.126

Lrrk2

3.02E-02

−0.372

1.294

4.21E-03

−0.412

1.331

1.00E + 00

−0.273

1.208

3.39E-01

−0.430

1.347

Ppp1r9a

3.21E-02

−0.265

1.201

1.15E-02

−0.269

1.205

1.00E + 00

−0.187

1.139

2.96E-01

−0.338

1.264

Traip

3.82E-02

−0.256

1.195

7.04E-02

−0.171

1.125

1.00E + 00

−0.146

1.106

6.65E-02

−0.453

1.369

Slc1a2

4.13E-02

−0.141

1.103

3.27E-02

−0.126

1.091

1.00E + 00

−0.164

1.120

6.16E-01

−0.133

1.097

Bank1

4.21E-02

−0.240

1.181

2.04E-03

−0.291

1.223

1.00E + 00

−0.131

1.095

2.73E-01

−0.298

1.229

Rnf8

4.72E-02

−0.116

1.084

7.03E-03

−0.130

1.094

1.00E + 00

−0.070

1.050

3.30E-01

−0.147

1.107

Up in YAC 128

            

Tmc3

1.30E-04

0.480

1.395

1.49E-04

0.374

1.296

2.27E-01

0.395

1.315

6.46E-04

0.672

1.593

Polr2a

2.30E-04

0.288

1.221

2.54E-03

0.230

1.173

6.81E-01

0.279

1.214

6.12E-02

0.354

1.278

Il17rb

9.51E-04

0.238

1.179

2.36E-05

0.270

1.206

9.04E-01

0.198

1.147

9.09E-02

0.246

1.186

Fat1

1.27E-03

0.277

1.212

6.20E-04

0.290

1.223

1.00E + 00

0.276

1.211

2.70E-01

0.265

1.201

Ppia (6 probes)

2.16E-03

0.188

1.139

1.65E-03

0.189

1.140

1.00E + 00

0.151

1.110

1.45E-01

0.224

1.168

Lrrn3

2.16E-03

0.280

1.214

7.46E-04

0.310

1.240

9.98E-01

0.290

1.223

4.51E-01

0.240

1.181

Chdh

4.11E-03

0.181

1.134

9.58E-03

0.160

1.117

1.00E + 00

0.177

1.130

2.60E-01

0.207

1.154

Acy3

4.57E-03

0.292

1.224

2.42E-02

0.171

1.126

2.57E-01

0.322

1.250

4.05E-02

0.383

1.304

Stat1

7.72E-03

0.203

1.151

4.04E-02

0.140

1.102

1.00E + 00

0.227

1.170

2.26E-01

0.244

1.184

Smoc1

1.61E-02

0.265

1.202

3.00E-02

0.190

1.141

1.00E + 00

0.257

1.195

1.38E-01

0.348

1.273

Rnf122

2.05E-02

0.186

1.138

9.00E-02

0.112

1.081

1.00E + 00

0.181

1.134

1.45E-01

0.264

1.201

Cited2

2.05E-02

0.246

1.186

1.89E-02

0.225

1.169

1.00E + 00

0.225

1.169

3.64E-01

0.288

1.221

Enpp6

2.05E-02

0.365

1.288

2.66E-02

0.257

1.195

1.00E + 00

0.335

1.261

9.29E-02

0.504

1.418

Spata5

2.29E-02

0.177

1.131

4.76E-03

0.202

1.150

1.00E + 00

0.183

1.135

6.69E-01

0.146

1.107

Htr2a

2.58E-02

0.362

1.285

4.80E-02

0.284

1.218

7.53E-01

0.469

1.384

6.08E-01

0.334

1.260

Arsb (2 probes)

2.61E-02

0.176

1.130

1.13E-02

0.180

1.133

1.00E + 00

0.104

1.075

2.33E-01

0.244

1.185

Grhpr

3.21E-02

0.188

1.139

4.07E-02

0.144

1.105

1.00E + 00

0.152

1.111

1.65E-01

0.270

1.205

Zfp488

3.55E-02

0.236

1.178

5.66E-01

0.040

1.028

2.27E-01

0.331

1.257

7.49E-02

0.338

1.264

Pla2g4a

3.55E-02

0.253

1.191

3.29E-02

0.172

1.127

1.00E + 00

0.251

1.190

1.17E-01

0.335

1.261

Pou6f2

4.02E-02

0.170

1.125

5.31E-02

0.141

1.103

1.00E + 00

0.152

1.111

3.87E-01

0.218

1.163

Eya1

4.21E-02

0.246

1.186

2.01E-02

0.223

1.167

1.00E + 00

0.233

1.175

3.90E-01

0.281

1.215

Ifit1

4.21E-02

0.383

1.304

8.37E-03

0.380

1.301

1.00E + 00

0.388

1.308

4.67E-01

0.382

1.303

Nfe2l3

4.27E-02

0.169

1.125

4.26E-02

0.109

1.079

1.00E + 00

0.067

1.048

1.29E-02

0.332

1.258

Plekhh2

4.72E-02

0.200

1.148

1.95E-05

0.284

1.218

1.00E + 00

0.144

1.105

3.90E-01

0.171

1.126

Mobkl2b

4.82E-02

0.225

1.169

2.45E-02

0.171

1.126

1.00E + 00

0.254

1.192

2.73E-01

0.251

1.190

  1. Probsets annotated to genes with a significant difference (FDR p < 0.05) between the two genotypes are given. Each gene corresponds to a single probeset unless indicated otherwise, the probeset of lowest p-value for all ages has been quoted in such cases. FC = fold change, AbsFC = absolute fold change.