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Table 3 Differentially expressed genes between WT and YAC128 striata identified using TANOVA

From: Similar striatal gene expression profiles in the striatum of the YAC128 and HdhQ150 mouse models of Huntington’s disease are not reflected in mutant Huntingtin inclusion prevalence

   WT
   Up NC Down Total
  Up 45 (13↓,31↑) 12(3↓,8↑) 16(6↓,9↑) 73(22↓,48↑)
YAC128 NC 10(7↓,2↑) 8(5↓,3↑) 7(4↓,3↑) 25(16↓,8↑)
  Down 17(10↓,2↑) 9(8↓,1↑) 22(21↓,1↑) 48(39↓,4↑)
  Total 72 29 45 146
  1. Numbers of genes significant for each TANOVA pattern of change over time, given as number (number of genes down-regulated in YAC128↓,number of genes up-regulated in YAC128↑): some genes showed a mixed pattern of change and have not been included. NC = no change. For instance in the top left hand corner, 45 genes were seen to increase in expression with age in YAC128 and wild-type striata, and of those 13 were reduced in expression in WT compared with YAC128 expression and 31 were increased in expression compared with YAC128 expression.