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Table 5 Genes that show significantly different patterns of differential expression between YAC128 and HdhQ150 striata

From: Similar striatal gene expression profiles in the striatum of the YAC128 and HdhQ150 mouse models of Huntington’s disease are not reflected in mutant Huntingtin inclusion prevalence

Symbol

Difference p

Q150 FC

YAC FC

Abs FC diff

Description

Actn2

1.07E-03

−0.19

−0.79

0.60

Actinin alpha 2

Htr2a

2.12E-04

−0.15

0.37

0.52

5-hydroxytryptamine (serotonin) receptor 2A

Ifit1

5.88E-03

−0.03

0.41

0.44

Interferon-induced protein with tetratricopeptide repeats 1

Galnt13

5.89E-05

−0.03

−0.45

0.42

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13

Htt

3.19E-10

−0.32

0.09

0.41

Huntingtin

Lgals3bp

9.45E-03

−0.04

0.36

0.40

Lectin, galactoside-binding, soluble, 3 binding protein

Iqub

3.74E-03

−0.33

0.04

0.37

IQ motif and ubiquitin domain containing

Ifi27l1

3.33E-04

−0.06

0.31

0.37

Interferon, alpha-inducible protein 27 like 1

Usp18

1.32E-03

−0.08

0.28

0.36

Ubiquitin specific peptidase 18

Dpp10

2.03E-03

−0.07

0.26

0.34

Dipeptidylpeptidase 10

Pkp2

9.91E-05

0.04

−0.29

0.33

Plakophilin 2

Olfr174

4.74E-03

0.15

−0.18

0.33

Olfactory receptor 174

Trim30

5.90E-04

−0.11

0.21

0.32

Tripartite motif-containing 30

Trpc6

6.67E-03

−0.27

0.02

0.29

Transient receptor potential cation channel, subfamily C, member 6

Zfp185

8.12E-03

−0.09

0.19

0.28

Zinc finger protein 185

Grk4

4.41E-03

−0.06

0.21

0.27

G protein-coupled receptor kinase 4

Acot9

4.17E-04

−0.10

0.17

0.26

Acyl-CoA thioesterase 9

Lgals2

6.58E-03

0.29

0.05

0.25

Lectin, galactose-binding, soluble 2

Rreb1

2.71E-03

−0.11

0.14

0.24

Ras responsive element binding protein 1

Dpysl5

1.39E-03

0.20

−0.04

0.24

Dihydropyrimidinase-like 5

Ceacam2

9.51E-03

−0.16

0.08

0.24

Carcinoembryonic antigen-related cell adhesion molecule 2

Wdr78

5.63E-03

−0.27

−0.03

0.24

WD repeat domain 78

Dnajc5g

5.58E-03

−0.11

0.13

0.23

DnaJ (Hsp40) homolog, subfamily C, member 5 gamma

Ccdc108

8.86E-03

−0.06

0.17

0.23

Coiled-coil domain containing 108

Plac8l1

3.01E-03

0.13

−0.10

0.23

PLAC8-like 1

Rell2

9.35E-03

0.19

−0.04

0.22

RELT-like 2

Tnfsf8

1.67E-03

0.10

−0.12

0.22

Tumor necrosis factor (ligand) superfamily, member 8

Pabpc1l2b

7.47E-03

0.20

−0.01

0.22

Poly(A) binding protein, cytoplasmic 1-like 2B

Slc13a5

7.14E-03

−0.15

0.07

0.21

Solute carrier family 13 (sodium-dependent citrate transporter), member 5

Irf9

1.68E-03

−0.05

0.16

0.21

Interferon regulatory factor 9

Ranbp2

5.60E-03

−0.17

0.04

0.21

RAN binding protein 2

Fut4

7.54E-03

−0.16

0.05

0.21

Fucosyltransferase 4

Tpbg

4.70E-03

0.09

−0.11

0.21

Trophoblast glycoprotein

Rnf213

4.48E-03

−0.01

0.20

0.20

Ring finger protein 213

Speer2

4.22E-03

0.14

−0.06

0.20

Spermatogenesis associated glutamate (E)-rich protein 2

V1rb3

5.18E-03

0.08

−0.12

0.20

Vomeronasal 1 receptor, B3

Setd1b

5.82E-03

0.13

−0.07

0.20

SET domain containing 1B

Dtl

1.26E-03

−0.10

0.09

0.20

Denticleless homolog (Drosophila)

  1. Genes with a significant interaction between YAC128 and HdhQ150 differential gene expression where the absolute fold change difference is > 0.20. FC = fold change, Abs FC = absolute fold change.