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Table 5 Genes that show significantly different patterns of differential expression between YAC128 and HdhQ150 striata

From: Similar striatal gene expression profiles in the striatum of the YAC128 and HdhQ150 mouse models of Huntington’s disease are not reflected in mutant Huntingtin inclusion prevalence

Symbol Difference p Q150 FC YAC FC Abs FC diff Description
Actn2 1.07E-03 −0.19 −0.79 0.60 Actinin alpha 2
Htr2a 2.12E-04 −0.15 0.37 0.52 5-hydroxytryptamine (serotonin) receptor 2A
Ifit1 5.88E-03 −0.03 0.41 0.44 Interferon-induced protein with tetratricopeptide repeats 1
Galnt13 5.89E-05 −0.03 −0.45 0.42 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13
Htt 3.19E-10 −0.32 0.09 0.41 Huntingtin
Lgals3bp 9.45E-03 −0.04 0.36 0.40 Lectin, galactoside-binding, soluble, 3 binding protein
Iqub 3.74E-03 −0.33 0.04 0.37 IQ motif and ubiquitin domain containing
Ifi27l1 3.33E-04 −0.06 0.31 0.37 Interferon, alpha-inducible protein 27 like 1
Usp18 1.32E-03 −0.08 0.28 0.36 Ubiquitin specific peptidase 18
Dpp10 2.03E-03 −0.07 0.26 0.34 Dipeptidylpeptidase 10
Pkp2 9.91E-05 0.04 −0.29 0.33 Plakophilin 2
Olfr174 4.74E-03 0.15 −0.18 0.33 Olfactory receptor 174
Trim30 5.90E-04 −0.11 0.21 0.32 Tripartite motif-containing 30
Trpc6 6.67E-03 −0.27 0.02 0.29 Transient receptor potential cation channel, subfamily C, member 6
Zfp185 8.12E-03 −0.09 0.19 0.28 Zinc finger protein 185
Grk4 4.41E-03 −0.06 0.21 0.27 G protein-coupled receptor kinase 4
Acot9 4.17E-04 −0.10 0.17 0.26 Acyl-CoA thioesterase 9
Lgals2 6.58E-03 0.29 0.05 0.25 Lectin, galactose-binding, soluble 2
Rreb1 2.71E-03 −0.11 0.14 0.24 Ras responsive element binding protein 1
Dpysl5 1.39E-03 0.20 −0.04 0.24 Dihydropyrimidinase-like 5
Ceacam2 9.51E-03 −0.16 0.08 0.24 Carcinoembryonic antigen-related cell adhesion molecule 2
Wdr78 5.63E-03 −0.27 −0.03 0.24 WD repeat domain 78
Dnajc5g 5.58E-03 −0.11 0.13 0.23 DnaJ (Hsp40) homolog, subfamily C, member 5 gamma
Ccdc108 8.86E-03 −0.06 0.17 0.23 Coiled-coil domain containing 108
Plac8l1 3.01E-03 0.13 −0.10 0.23 PLAC8-like 1
Rell2 9.35E-03 0.19 −0.04 0.22 RELT-like 2
Tnfsf8 1.67E-03 0.10 −0.12 0.22 Tumor necrosis factor (ligand) superfamily, member 8
Pabpc1l2b 7.47E-03 0.20 −0.01 0.22 Poly(A) binding protein, cytoplasmic 1-like 2B
Slc13a5 7.14E-03 −0.15 0.07 0.21 Solute carrier family 13 (sodium-dependent citrate transporter), member 5
Irf9 1.68E-03 −0.05 0.16 0.21 Interferon regulatory factor 9
Ranbp2 5.60E-03 −0.17 0.04 0.21 RAN binding protein 2
Fut4 7.54E-03 −0.16 0.05 0.21 Fucosyltransferase 4
Tpbg 4.70E-03 0.09 −0.11 0.21 Trophoblast glycoprotein
Rnf213 4.48E-03 −0.01 0.20 0.20 Ring finger protein 213
Speer2 4.22E-03 0.14 −0.06 0.20 Spermatogenesis associated glutamate (E)-rich protein 2
V1rb3 5.18E-03 0.08 −0.12 0.20 Vomeronasal 1 receptor, B3
Setd1b 5.82E-03 0.13 −0.07 0.20 SET domain containing 1B
Dtl 1.26E-03 −0.10 0.09 0.20 Denticleless homolog (Drosophila)
  1. Genes with a significant interaction between YAC128 and HdhQ150 differential gene expression where the absolute fold change difference is > 0.20. FC = fold change, Abs FC = absolute fold change.