Table 3 Down-regulated proteins involved in homeostasis and energy metabolism in Red Sea newly released nauplii larvae of B.amphitrite

Detoxification

AGA83299.1

143917_1

glutamine synthetase (GS)

1

6

2.1

0.046

EKC40774.1

381680_1

glutaredoxin(GRX)

1

15

2.34

0.021

EFX81633.1

352718_6

glutathione S-transferase (GST)

2

18

2.24

0.053

NP_001108460.1

176458_3

glutathione S-transferase epsilon 4 (GST4)

4

44

2.24

0.014

XP_537038.2

68758_2

glutathione S-transferase Mu 1 isoform 1 (GST Mu1)

2

9

1.73

0.098

XP_003693286.1

382037_1

aldehyde oxidase 2 (AO2)

1

6

2.01

0.129

EHJ73729.1

382498_5

alcohol dehydrogenase (ADH)

1

4

1.77

0.028

AEE36486.1

326926_1 (+1)

protein disulfide isomerase 2 (PDI2)

6

47

1.6

0.017

AFL70280.1

281344_8 (+1)

protein disulfide-isomerase A6 (PDIA6)

1

8

1.83

0.09

Transport

XP_002431951.1

15248_12

dynein heavy chain, cytosolic (DHC)

1

1

5.16

0.228

XP_002426223.1

129454_5

mitochondrial import inner membrane translocase subunit Tim23 (TIMM23)

1

9

1.75

0.043

EFX90424.1

283903_1

mitochondrial inner membrane protein (MIM)

2

14

1.84

0.128

XP_967948.2

299347_2

bumetanide sensitive NaK2Cl cotransporter isoform 1 (NKCC2)

1

9

1.75

0.095

ADM64456.1

378620_1 (+1)

fatty acid binding protein (FABP)

5

44

1.93

0.028

XP_393519.1

237152_4 (+3)

fatty acid-binding protein, adipocyte (FABPA)

1

11

1.92

0.177

XP_001601236.1

34337_3 (+1)

nuclear transport factor 2 (NTF2)

1

9

2.06

0.017

XP_973673.1

301328_8

vesicle associated protein (VAP)

3

5

1.78

0.067

XP_002737711.1

360183_6 (+2)

coated vesicle membrane protein- isoform 2 (VAMP-2)

1

11

1.91

0.014

EGF79988.1

198964_4

peptidyl-prolyl cis-trans isomerase (PPI)

2

94

2.81

0.123

ACJ05313.1

307444_1 (+1)

leucine aminopeptidase(LAPs)

1

9

1.74

0.064

Glycolysis/gluconeogenesis

ACD75898.1

360305_3

enolase (EN)

1

43

2.21

0.159

AAS02310.1

286350_2 (+1)

glyceraldehyde 3-phosphate dehydrogenase (GPDH)

1

77

5.75

0.043

AGC97435.1

281394_3

glycogen phosphorylase (GPs)

1

12

1.66

0.057

XP_002400796.1

278577_6

GDP-mannose pyrophosphorylase (GDP-MP)

1

3

2.1

0.043

XP_003393705.1

130725_2 (+2)

transketolase 2 isoform 1 (TKT2)

2

14

1.7

0.014

Q91XV4.1

312847_2

L-xylulose reductase (XRs)

1

11

1.71

0.028

BAJ23881.1

360259_3

fructose 1,6-bisphosphatase (FDPase)

2

21

3.54

0.035

ACH81781.1

242946_2

fructose 1,6-bisphosphate aldolase (FBPA)

7

32

2.05

0.014

XP_001601687.1

383275_9

phosphoglucomutase-2- isoform 1 (PGM 2)

1

4

1.66

0.057

XP_003240970.1

383186_3

pyruvate carboxylase, mitochondrial- isoform 3(PCm3)

2

15

1.91

0.095

EKC25154.1

284278_2 (+1)

UTP--glucose-1-phosphate uridylyltransferase (GalU)

1

7

2.28

0.035

XP_001847482.1

255952_3

UTP-glucose-1-phosphate uridylyltransferase 2 (GalU2)

2

11

2.53

0.176

Actin-binding proteins

XP_001944078.1

370072_2

vinculin (VCL)

1

19

1.62

0.035

CCI71880.1

97015_4

gelsolin (GSN)

1

15

1.55

0.039

XP_001657431.1

377569_1 (+1)

gelsolin precursor(GSNP)

2

18

1.71

0.043

XP_003691411.1

216_3

plastin-3(PLS3)

2

10

1.71

0

JAA59814.1

237239_4

villin-1 (VIL1)

3

27

1.81

0.028