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Fig. 11 | BMC Genomics

Fig. 11

From: Epigenetic modification with trichostatin A does not correct specific errors of somatic cell nuclear transfer at the transcriptomic level; highlighting the non-random nature of oocyte-mediated reprogramming errors

Fig. 11

TSA differently affects fibroblast gene expression. Almost transcripts (panels a, b, and c), except for the UBD transcript (panel d), were altered after TSA treatment of fibroblasts. Alterations in LAMA1, CXXC5, and ARPC1B resulted in subsequent correction of their expression in TSA-NT blastocyst when compared to IVF. However, alterations in ARHGEF6, SAP30L, MT1A, RAB9A and OXCT1 resulted in subsequent over-compensation of these genes compared to IVF. On the other hand, alterations in STEAP2, HIST2H2B, SFN, SOR1, LIX1L, and PPP1R5B resulted in their subsequent under-compensation in TSA-NT blastocysts

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BMC Genomics

ISSN: 1471-2164

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