Fig. 1

RNA-binding abilities of S. cerevisiae chaperone substrates. a RNA-binding ability of yeast chaperones substrates is visualized in a microarray-like table. Hsp90 and Hsp40 are predicted to have the largest number of nucleic-acid binding partners (Positive set: vertical axis; Negative set: horizontal axis; Green: positive set is enriched with respect to negative set; Red: negative set is enriched with respect to positive set [3]; Yellow: non significant enrichment; Grey: not calculable enrichment due strong overlap between the sets). The enrichment is associated with a p-value < 10⁻⁵ calculated with Fisher’s exact test. b GO annotations are shown through an innovative interface that allows clustering through semantic similarity. The largest cluster of Hsp90 interactors is related to the molecular function (MF) RNA/DNA binding (red cluster corresponding to a coverage of 372 out of 877 proteins). Full analysis is available at http://www.tartaglialab.com/cs_multi/confirm/286/d67c93dd10/