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Table 7 The estimated hyperparameters π 0 and \({\sigma _{0}^{2}}\) for 6 diseases of WTCCC dataset

From: Power estimation and sample size determination for replication studies of genome-wide association studies

 

\(\widehat {\pi }_{0}\)

\(\widehat {\sigma }_{0}^{2}\)

Coronary artery disease

0.949

0.004

Crohn’s disease

0.840

0.006

Hypertension

0.966

0.007

Rheumatoid arthritis

0.947

0.008

Type 1 diabetes

0.967

0.014

Type 2 diabetes

0.940

0.005

  1. π 0 is the proportion of true null hypotheses among all SNPs. \({\sigma _{0}^{2}}\) is the variance of the effect sizes among all associated SNPs
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BMC Genomics

ISSN: 1471-2164

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