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Table 9 Sample size of the replication study needed for 6 diseases of WTCCC dataset when average power is estimated by plugging in observed effect sizes. The Control-to-Case ratio of the replication study is set to 1. The significance levels used in the primary study and the replication study are α 1=5×10−8 and α 2=5×10−6, respectively

From: Power estimation and sample size determination for replication studies of genome-wide association studies

 

50 %

60 %

70 %

80 %

90 %

Coronary artery disease

2019

2290

2608

3023

3675

Crohn’s disease

2270

2572

2922

3369

4058

Hypertension

2672

2988

3345

3788

4448

Rheumatoid arthritis

1553

1892

2273

2748

3465

Type 1 diabetes

1532

1856

2229

2706

3443

Type 2 diabetes

2085

2357

2676

3095

3775