Table 2 Table summarizing categories of genes with strong positive (PCC >0.7) and negative correlation (PCC <−0.7) of expression with that of both pfcrt and pfmdr1. Genes correlated or anticorrelated with pfcrt and pfmdr1 transcript levels

Transporters/Components of the digestive vacuole

PF3D7_0519200

vacuolar ATP synthetase

PF3D7_0614300

organic anion transporter

PF3D7_0810200

ABC1 family, putative (ABCK1)

PF3D7_1132500

amino acid transporter, putative

PF3D7_1354400

V-type ATPase, putative

PF3D7_1456800

V-type H()-translocating pyrophosphatase, putative

PF3D7_1129900

transporter, putative

PF3D7_1454400

aminopeptidase P

PF3D7_1126000

threonine--tRNA ligase (ThrRS)

PF3D7_1332800

translation initiation factor 6, putative

Translation

PF3D7_1367700

alanine--tRNA ligase (AlaRS)

PF3D7_1445100

histidine--tRNA ligase, putative

PF3D7_1204300

eukaryotic translation initiation factor 5A (EIF5A)

PF3D7_0422500

pre-mRNA-splicing helicase BRR2, putative (BRR2)

RNA metabolism

PF3D7_0623900

ribonuclease H2 subunit A, putative

PF3D7_1421400

DNA-directed RNA polymerase III subunit C, putative

DNA/RNA metabolism

PF3D7_1125300

DNA-dependent RNA polymerase

PF3D7_0105900

DNA binding protein, putative

PF3D7_0617800

histone H2A

PF3D7_1033600

Myb2 protein

PF3D7_0716100

large ribosomal subunit assembling factor, putative

PF3D7_0420400

ribosome recycling factor, putative

RNA processing/Translation

PF3D7_0610100

step II splicing factor, putative

PF3D7_1446900

glutaminyl-peptide cyclotransferase, putative

PF3D7_0904600

ubiquitin specific protease, putative

Protein Catabolism

PF3D7_0815700

ubiquitin

PF3D7_0413600

26S proteasome AAA-ATPase subunit RPT3, putative

Transporters

PF3D7_1303500

sodium/hydrogen exchanger, Na, H antiporter

PF3D7_1352100

ABC transporter, (heavy metal transporter family), putative