Table 3 Top 25 upregulated pathways in kawasaki disease coronary arteries
From: The transcriptional profile of coronary arteritis in Kawasaki disease
Upregulated pathways | # of differentially expressed genes | p-value |
|---|---|---|
Primary immunodeficiency signaling | 26 | 5.65E-21 |
Communication between innate and adaptive immune cells | 30 | 1.08E-17 |
iCOS-iCOSL signaling in T helper cells | 32 | 3.12E-17 |
Altered T cell and B cell signaling in rheumatoid arthritis | 29 | 3.84E-17 |
B cell development | 17 | 3.62E-14 |
CD28 signaling in T helper cells | 28 | 1.35E-12 |
Role of NFAT in regulation of the immune response | 33 | 6.43E-12 |
PKCθ signaling in T lymphocytes | 27 | 8.5E-12 |
Autoimmune thyroid disease signaling | 17 | 5.1E-11 |
Hematopoiesis from pluripotent stem cells | 17 | 1.06E-10 |
T cell receptor signaling | 23 | 1.38E-10 |
Antigen presentation pathway | 14 | 6.89E-10 |
Calcium-induced T lymphocyte apoptosis | 18 | 7.03E-10 |
Crosstalk between dendritic cells and natural killer cells | 21 | 9.61E-10 |
Systemic lupus erythematosus signaling | 34 | 1.8E-09 |
Allograft rejection signaling | 20 | 3.16E-09 |
Graft-versus-host disease signaling | 15 | 3.7E-09 |
T helper cell differentiation | 18 | 4.41E-09 |
CTLA4 signaling in cytotoxic T lymphocytes | 20 | 4.84E-09 |
Nur77 signaling in T lymphocytes | 16 | 6.42E-09 |
Dendritic cell maturation | 29 | 8.49E-09 |
Agranulocyte adhesion and diapedesis | 29 | 2.97E-08 |
OX40 signaling pathway | 19 | 3.48E-08 |
Natural killer cell signaling | 21 | 5.32E-08 |
Hepatic fibrosis/Hepatic stellate cell activation | 29 | 7.53E-08 |