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Table 2 List of proteins selected for experimental yeast two-hybrid evaluation

From: Using host-pathogen protein interactions to identify and characterize Francisella tularensis virulence factors

Group

Locus ID

Name

Description

Interactions

Human

Mouse

Common

1

FTT0369c

DipA

Deficient in intracellular replication A

-

-

-

FTT0584

-

Unknown

-

-

-

FTT0901

LpnA

Lipoprotein

-

1

-

FTT0918

FopC

Outer membrane lipoprotein

-

-

-

FTT1103

DsbA

Conserved hypothetical lipoprotein

-

-

-

FTT1179

BipA

GTP binding translational elongation factor Tu

29

-

-

FTT1508c

RelA

GTP pyrophosphokinase

3

-

-

FTT1726

YegQ

Protease YegQ

-

-

-

FTT1676

-

Protein of unknown function, membrane protein

-

-

-

FTT0356

HtpG

Chaperone, heat shock protein HtpG, ATPase activity

20

1

1

FTT0626

Lon

Chaperone, ATP-dependent DNA-binding protease Lon

2

2

-

FTT1769c

ClpB

Chaperone, ATP-dependent CLP protease ATP-binding subunit ClpB

-

-

-

FTT1712c

IglC2

Intracellular growth locus, subunit C

43

33

1

FTT0068

SodB

Superoxide dismutase

-

12

-

FTT1707

IglI2

Uncharacterized protein

-

-

-

2

FTT0013c

-

Protein of unknown function

-

-

-

FTT0295

-

Hypothetical protein

-

-

-

FTT0520

-

Putative uncharacterized protein

-

-

-

FTT0842

-

Peptidoglycan-associated lipoprotein

9

17

-

FTT0902

-

Protein of unknown function

8

1

-

FTT0975

-

Protein of unknown function

-

-

-

FTT1039

DacB1

d-Alanyl-d-alanine carboxypeptidase (penicillin-binding protein) family protein

-

-

-

FTT1040

-

Lipoprotein

-

-

-

FTT1334c

-

Hypothetical protein

1

1

-

FTT1402c

-

Protein of unknown function

-

-

-

FTT1538c

-

Hypothetical protein

25

22

-

FTT1549

-

Protein of unknown function

-

-

-

FTT1626c

-

Hypothetical protein

-

-

-

FTT1688

-

Aromatic amino acid HAAP transporter

-

-

-

FTT1314c

PilE6

Type IV pili fiber building block protein

4

-

-

FTT1776c

-

Hypothetical protein

2

-

-

3

FTT0086

-

Conserved protein of unknown function

-

-

-

FTT0103c

-

Hypothetical protein

2

-

-

FTT0792

-

LPS locus

-

-

-

FTT0889c

-

Type IV pili fiber building block protein

-

-

-

FTT1530

FadB/AcbP

Bifunctional 3-hydroxacyl-CoA dehydrogenase

-

-

-

FTT1564

-

Polyphosphate kinase

9

6

1

4

FTT0018

-

Secretion protein

10

-

-

FTT0296

Pcp

Pyrrolidone-carboxylate peptidase

-

-

-

FTT0482c

-

Lipoprotein

32

14

11

FTT1029

DacD

d-Alanyl-d-alanine carboxypeptidase (penicillin binding protein) family protein

5

2

2

FTT1157c

-

Type IV pili lipoprotein

-

-

-

FTT1242

-

Hypothetical protein

-

-

-

FTT1591

VacJ

Lipoprotein

-

-

-

FTT1746

-

Peptidase

-

-

-

5

FTT1597

-

Putative uncharacterized protein

16

6

6

FTT0522

-

Hypothetical protein, methyltransferase domain

-

-

-

FTT0604

-

Hypothetical protein, methyltransferase domain

-

-

-

FTT0677c

-

Putative uncharacterized protein

2

-

-

  1. Group 1, multiple virulence association evidences and evidence about attenuation in an animal model; group 2, multiple virulence association evidences; group 3, transposon mutant screening evidence only; group 4, predicted secretion evidence only; group 5, orthology evidence only