Fig. 5
From: Improved transcription and translation with L-leucine stimulation of mTORC1 in Roberts syndrome
Imprinted genes are differentially expressed in RBS cells. a A heatmap displays the expression pattern of various imprinted genes in RBS and corrected cells with or without L-Leu. b The histograms show the average from three biological samples and the error bar indicates the standard deviation. The results are shown from 24 h treatment with L-Leu. The data from the 3 h treatment showed a similar pattern. H19 was upregulated ~ 4 fold in the mutant cells relative to the corrected cells. c The micro-RNA 675 was elevated ~ 3 fold in the mutant cells. d The imprinted MEG3/GTL2 and MEG8/Rian genes were markedly increased in expression in RBS cells