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Table 2 KEGG functional modules distinctive for the P. aeruginosa pangenome gene category

From: Pangenome-wide and molecular evolution analyses of the Pseudomonas aeruginosa species

KEGG module number

Description

Genes

Core genome

 M00064

ADP-L-glycero-D-manno-heptose biosynthesis

2

 M00493

AlgZ-AlgR (alginate production) two-component regulatory system

1

 M00235

Arginine/ornithine transport system

3

 M00531

Assimilatory nitrate reduction

1

 M00475

BarA-UvrY (central carbon metabolism) two-component regulatory system

2

 M00086

Beta-Oxidation

1

 M00123, M00573, M00577

Biotin biosynthesis

3

 M00364, M00366

C10-C20 isoprenoid biosynthesis

2

 M00170, M00171

C4-dicarboxylic acid cycle

2

 M00168

CAM (Crassulacean acid metabolism)

1

 M00722, M00727, M00728

Cationic antimicrobial peptide (CAMP) resistance

3

 M00256

Cell division transport system

1

 M00010

Citrate cycle

4

 M00120

Coenzyme A biosynthesis

3

 M00338

Cysteine biosynthesis

1

 M00154, M00155

Cytochrome c oxidase

3

 M00417

Cytochrome o ubiquinol oxidase

3

 M00552

D-galactonate degradation, De Ley-Doudoroff pathway

2

 M00596

Dissimilatory sulfate reduction

1

 M00542

EHEC/EPEC pathogenicity signature

2

 M00008

Entner-Doudoroff pathway

1

 M00445

EnvZ-OmpR (osmotic stress response) two-component regulatory system

3

 M00515

FlrB-FlrC (polar flagellar synthesis) two-component regulatory system

1

 M00729

Fluoroquinolone resistance

1

 M00344, M00345

Formaldehyde assimilation

3

 M00497

GlnL-GlnG (nitrogen regulation) two-component regulatory system

1

 M00605

Glucose/mannose transport system

2

 M00012

Glyoxylate cycle

1

 M00050

Guanine ribonucleotide biosynthesis, IMP

3

 M00259

Heme transport system

1

 M00045

Histidine degradation

4

 M00226

Histidine transport system

1

 M00620

Incomplete reductive citrate cycle

3

 M00131

Inositol phosphate metabolism

1

 M00190

Iron (III) transport system

4

 M00535

Isoleucine biosynthesis

3

 M00113

Jasmonic acid biosynthesis

1

 M00505

KinB-AlgB (alginate production) two-component regulatory system

2

 M00080

Lipopolysaccharide biosynthesis

1

 M00320

Lipopolysaccharide export system

2

 M00255

Lipoprotein-releasing system

1

 M00116

Menaquinone biosynthesis

1

 M00740

Methylaspartate cycle

2

 M00189

Molybdate transport system

3

 M00711

Multidrug resistance, efflux pump MdtIJ

1

 M00115

NAD biosynthesis

3

 M00144

NADH:quinone oxidoreductase

13

 M00471

NarX-NarL (nitrate respiration) two-component regulatory system

1

 M00622

Nicotinate degradation

1

 M00615

Nitrate assimilation

2

 M00438

Nitrate/nitrite transport system

1

 M00439

Oligopeptide transport system

1

 M00209

Osmoprotectant transport system

2

 M00004, M00007

Pentose phosphate pathway

6

 M00024

Phenylalanine biosynthesis

3

 M00434

PhoR-PhoB (phosphate starvation response)

1

 M00222

Phosphate transport system

4

 M00501

PilS-PilR (type 4 fimbriae synthesis) two-component regulatory system

1

 M00133

Polyamine biosynthesis

3

 M00015

Proline biosynthesis

3

 M00247, M00258

Putative ABC transport system

3

 M00193

Putative spermidine/putrescine transport system

7

 M00046

Pyrimidine degradation

1

 M00053

Pyrimidine deoxyribonuleotide biosynthesis, CDP/CTP

5

 M00052

Pyrimidine ribonucleotide biosynthesis, UMP

3

 M00377

Reductive acetyl-CoA pathway (Wood-Ljungdahl pathway)

1

 M00167

Reductive pentose phosphate cycle

5

 M00523

RegB-RegA (redox response) two-component regulatory system

2

 M00125

Riboflavin biosynthesis, GTP

2

 M00394

RNA degradosome

1

 M00308

Semi-phosphorylative Entner-Doudoroff pathway

2

 M00185

Sulfate transport system

2

 M00436

Sulfonate transport system

3

 M00435

Taurine transport system

1

 M00089

Triacylglycerol biosynthesis

2

 M00332

Type III secretion system

2

 M00025, M00040

Tyrosine biosynthesis

4

 M00117, M00128

Ubiquinone biosynthesis

7

 M00029

Urea cycle

3

 M00651

Vancomycin resistance

2

 M00241

Vitamin B12 transport system

1

 M00660

Xanthomonas spp. pathogenicity signature

2

 M00242

Zinc transport system

2

Accessory genome

 M00502

GlrK-GlrR (amino sugar metabolism) two-component regulatory system

1

 M00533

Homoprotocatechuate degradation

2

 M00240

Iron complex transport system

3

 M00005

PRPP biosynthesis

1

 M00473

UhpB-UhpA (hexose phosphates uptake) two-component regulatory system

1

 M00644

Vanadium resistance

1

Unique genes

 M00653

AauS-AauR (acidic amino acids utilization) two-component regulatory system

1

 M00500

AtoS-AtoC (cPHB biosynthesis) two-component regulatory system

1

 M00450

BaeS-BaeR (envelope stress response) two-component regulatory system

1

 M00104

Bile acid biosynthesis

1

 M00581

Biotin transport system

1

 M00569

Catechol meta-cleavage

4

 M00582

Energy-coupling factor transport system

1

 M00760

Erythromycin resistance

1

 M00524

FixL-FixJ (nitrogen fixation) two-component regulatory system

1

 M00713

Fluoroquinolone resistance

1

 M00059

Glycosaminoglycan biosynthesis

1

 M00499

HydH-HydG (metal tolerance) two-component regulatory system

1

 M00714, M00645

Multidrug resistance

2

 M00664

Nodulation

1

 M00549

Nucleotide sugar biosynthesis

1

 M00267

PTS system, N-acetylglucosamine-specific II component

1

  1. Catalogue of the KEGG functional modules (M) distinctively found in three gene categories of the P. aeruginosa pangenome: core, accessory, and unique genes. The number of modules correlated with those numbers presented in Fig. 2 (Venn diagram on the right)