|
AUC0.05
|
Data set 1: (Qin 2010)
|
Data set 2: (Yatsunenko 2012)
|
|---|
|
Group Size
|
3 + 3
|
6 + 6
|
10 + 10
|
3 + 3
|
6 + 6
|
10 + 10
|
|
edgeR
|
0.64
|
0.77
|
0.85
|
0.55
|
0.80
|
0.92
|
|
DESeq2
|
0.70
|
0.80
|
0.86
|
0.53
|
0.78
|
0.90
|
|
OGLM
|
0.64
|
0.83
|
0.90
|
0.44
|
0.73
|
0.88
|
|
MetagenomeSeq
|
0.29
|
0.68
|
0.87
|
0.41
|
0.70
|
0.86
|
|
Metastats
|
0.19
|
0.74
|
0.79
|
0.18
|
0.66
|
0.84
|
|
Voom
|
0.63
|
0.74
|
0.78
|
0.48
|
0.70
|
0.83
|
|
Sqrt t-test
|
0.62
|
0.78
|
0.85
|
0.43
|
0.70
|
0.86
|
|
Log t-test
|
0.63
|
0.76
|
0.79
|
0.44
|
0.69
|
0.84
|
|
t-test
|
0.56
|
0.77
|
0.85
|
0.38
|
0.67
|
0.84
|
|
Welch t-test
|
0.47
|
0.74
|
0.83
|
0.32
|
0.62
|
0.82
|
|
WMW
|
-----
|
0.75
|
0.83
|
-----
|
0.66
|
0.84
|
|
Binomial
|
0.40
|
0.46
|
0.48
|
0.33
|
0.51
|
0.67
|
|
GLM
|
0.32
|
0.35
|
0.36
|
0.34
|
0.52
|
0.68
|
|
Fisher’s exact test
|
0.32
|
0.35
|
0.36
|
0.33
|
0.51
|
0.67
|
- Each listed value is the normalized area under curve up until a false positive rate of 0.05. Higher values represent higher gene ranking performance. The results are calculated based on 100 resampled metagenomes. The Wilcoxon-Mann–Whitney test was not evaluated at the smallest sample size (3 + 3) due to lack of samples. The full area under curve (AUC) measurements are available in Additional file 1: Table S1
