Fig. 5
From: Cascade: an RNA-seq visualization tool for cancer genomics
An example use-case of Cascade. A representation of the biological pathway for MAP2K4 published by Zhengyan et al. is shown with CNV and mutation data adapted from the analysis of ovarian cancers. The increased frequency of CNV gains in oncogenes (e.g. AKT, PI3K, RAF) and loss in tumor suppressors (e.g. NF1, PTEN) are evident while mutations in oncogenes and tumor suppressors (red nodes) are also displayed