The first genome sequence of a metatherian herpesvirus: Macropodid herpesvirus 1

Vaz, Paola K.; Mahony, Timothy J.; Hartley, Carol A.; Fowler, Elizabeth V.; Ficorilli, Nino; Lee, Sang W.; Gilkerson, James R.; Browning, Glenn F.; Devlin, Joanne M.

doi:10.1186/s12864-016-2390-2

BMC Genomics

Table 1 Predicted open reading frames (ORFs) identified in different structural regions of the Macropodid herpesvirus 1 genome and percentage pairwise amino acid identity to ORFs in related alphaherpesviruses

From: The first genome sequence of a metatherian herpesvirus: Macropodid herpesvirus 1

				% aa pairwise identity^#
ORF	Length (nt)	Length (aa)	Description (putative) ^§	MaHV2	MaHV4	HHV1	HHV2
Unique short region
US1	1392	463	Infected cell protein 22; ICP22			29	35
US2	867	288	Tegument protein			49	49
US3	1449	482	Protein kinase			56	59
US4	360	119	Glycoprotein G; predicted non-functional	59	63	32	35
US6	1188	395	Glycoprotein D	74		56	57
US7	1392	463	Glycoprotein I	58		38	39
US8	1599	532	Glycoprotein E	63		34	32
PW2	342	113	Unique hypothetical
PW3	582	193	Unique hypothetical
PW4	1023	340	Unique hypothetical
PW5	1233	410	Unique hypothetical
Inverted repeat region
PW1	453	150	Unique hypothetical
ICP4	3708	1235	Infected cell protein 4; ICP4			51	50
TS	951	316	Thymidylate synthase; host-derived
ICP34.5	900	299	Infected cell protein 34.5; ICP34.5			62	56
ICP0	1629	542	Infected cell protein 0; ICP0			50	51
Unique long region
UL1	579	192	Glycoprotein L			41	47
UL2	906	301	Uracil-DNA glycosylase			59	60
UL5	2601	866	Helicase-primase helicase subunit			73	73
UL6	2007	668	Capsid portal protein			62	63
UL7	888	295	Tegument protein			51	49
UL8	2253	750	Helicase-primase subunit			38	39
UL9	2616	871	DNA replication origin-binding helicase			70	70
UL10	1347	448	Glycoprotein M			51	48
UL11	246	81	Myristoylated tegument protein			45	59
UL12	1749	582	Alkaline exonuclease; deoxyribonuclease			56	56
UL13	1845	614	Tegument serine/threonine protein kinase			48	47
UL14	645	214	Tegument protein			60	63
UL15	2100	699	DNA packaging terminase subunit 1			70	71
UL16	1098	365	Tegument protein			51	54
UL17	2184	727	DNA packaging tegument protein			51	50
UL18	951	316	Capsid triplex subunit 2			68	68
UL19	4131	1376	Major capsid protein			69	70
UL20	648	215	Envelope protein			45	43
UL21	1596	531	Tegument protein			43	43
UL22	2631	876	Glycoprotein H			45	45
UL23	1062	353	Thymidine kinase	76		42	44
UL24	702	233	Nuclear protein			52	53
UL25	1740	579	DNA packaging tegument protein			61	61
UL26	1761	586	Capsid maturation protease			53	52
UL27	2664	887	Glycoprotein B	83	82	72	70
UL28	2325	774	DNA packaging terminase subunit 2			64	63
UL29	3579	1192	ICP8; single stranded binding protein			70	69
UL30	3675	1224	DNA polymerase			66	66
UL31	921	306	Nuclear egress lamina protein			73	72
UL32	1731	576	DNA packaging protein			62	61
UL33	390	129	DNA packaging protein			61	60
UL34	837	278	Nuclear egress membrane protein			44	43
UL35	408	135	Small capsid protein			53	50
UL36	8535	2844	Large tegument protein			48	48
UL37	3150	1049	Tegument protein			46	45
UL38	1359	452	VP19C; capsid triplex subunit 1			56	56
UL39	2916	971	Ribonucleotide reductase subunit 1			65	66
UL40	990	329	Ribonucleotide reductase subunit 2			65	65
UL41	1566	521	Tegument host shutoff protein			60	61
UL42	1422	473	DNA polymerase processivity subunit			44	44
UL44	1296	431	Glycoprotein C			36	34
UL45	516	171	Membrane protein			42	40
UL46	2343	780	VP11/12; tegument protein			49	49
UL47	2133	710	VP13/14; tegument protein			43	42
UL48	1497	498	VP16; transactivating tegument protein			47	47
UL49	777	258	VP22; tegument protein			67	67
UL49A	324	107	Glycoprotein N				32
UL50	1035	344	Deoxyuridine triphosphatase			39	35
UL51	741	246	Tegument protein			67	66
UL52	3102	1033	Helicase primase subunit			59	58
UL53	1023	340	Glycoprotein K			46	47
UL54	1524	507	ICP27; multifunctional expression regulator			52	52
UL55	540	179	Nuclear protein			40	36
PW6	630	209	Unique hypothetical

^§Putative function of encoded polypeptides in MaHV-1
^#amino acid identities with homologues in Human herpesvirus 1 and 2 (HHV1 and HHV2) and Macropodid herpesviruses 2 and 4 (MaHV2 and MaHV4)

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ISSN: 1471-2164

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