Table 1 The top 20 hypermethylated a-CpGs in middle-aged individuals. The hypermethylated and hypomethylated a-CpGs are shown separately in Tables 1 and 2, respectively. The top-ranking hypermethylated a-CpGs were selected with the following criteria: 1) direction of the association based on the value of beta regression (denoted as ‘betareg’) estimate of age; 2) more than one hit identified per gene (q-value < 0.05 which corresponds to false discovery rate <5 %) and 3) the top-ranking p-values. The full list of a-CpGs is shown in Additional file 3: Table S4. The q-value denotes the Benjamini-Hochberg-corrected p-value
From: Aging-associated DNA methylation changes in middle-aged individuals: the Young Finns study
ProbeID | Gene name | CHR | Coordinate | Betareg estimate of age | q-value |
|---|---|---|---|---|---|
cg16867657 | ELOVL2 | 6 | 11152863 | 0.022 | 0.00E + 00 |
cg24724428 | ELOVL2 | 6 | 11152874 | 0.021 | 4.80E-07 |
cg21572722 | ELOVL2 | 6 | 11152880 | 0.013 | 3.46E-06 |
cg06639320 | FHL2 | 2 | 105382171 | 0.018 | 3.46E-06 |
cg00059225 | GLRA1 | 5 | 151284550 | 0.013 | 5.13E-06 |
cg08097417 | KLF14 | 7 | 130069673 | 0.020 | 1.87E-05 |
cg22454769 | FHL2 | 2 | 105382199 | 0.021 | 5.03E-05 |
cg07553761 | TRIM59 | 3 | 161650671 | 0.016 | 6.12E-05 |
cg01588592 | ETV3L | 1 | 155335949 | 0.011 | 1.14E-04 |
cg11176990 | LOC375196 | 2 | 39041037 | 0.014 | 1.54E-03 |
cg09499629 | KLF14 | 7 | 130069676 | 0.018 | 1.54E-03 |
cg22158769 | LOC375196 | 2 | 39041043 | 0.020 | 2.43E-03 |
cg18898125 | NEFM | 8 | 24826286 | 0.012 | 2.49E-03 |
cg21911021 | ZIK1 | 19 | 62786823 | 0.020 | 3.07E-03 |
cg27217742 | RGS12 | 4 | 3335078 | 0.013 | 3.07E-03 |
cg17737681 | DLX1 | 2 | 172660382 | 0.015 | 3.29E-03 |
cg24079702 | FHL2 | 2 | 105382203 | 0.015 | 5.99E-03 |
cg16219603 | PENK | 8 | 57523140 | 0.013 | 7.00E-03 |
cg23930856 | TFAP2B | 6 | 50919683 | 0.013 | 7.22E-03 |
cg11152943 | TRAPPC9 | 8 | 141318170 | 0.013 | 7.57E-03 |