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Table 1 The top 20 hypermethylated a-CpGs in middle-aged individuals. The hypermethylated and hypomethylated a-CpGs are shown separately in Tables 1 and 2, respectively. The top-ranking hypermethylated a-CpGs were selected with the following criteria: 1) direction of the association based on the value of beta regression (denoted as ‘betareg’) estimate of age; 2) more than one hit identified per gene (q-value < 0.05 which corresponds to false discovery rate <5 %) and 3) the top-ranking p-values. The full list of a-CpGs is shown in Additional file 3: Table S4. The q-value denotes the Benjamini-Hochberg-corrected p-value

From: Aging-associated DNA methylation changes in middle-aged individuals: the Young Finns study

ProbeID Gene name CHR Coordinate Betareg estimate of age q-value
cg16867657 ELOVL2 6 11152863 0.022 0.00E + 00
cg24724428 ELOVL2 6 11152874 0.021 4.80E-07
cg21572722 ELOVL2 6 11152880 0.013 3.46E-06
cg06639320 FHL2 2 105382171 0.018 3.46E-06
cg00059225 GLRA1 5 151284550 0.013 5.13E-06
cg08097417 KLF14 7 130069673 0.020 1.87E-05
cg22454769 FHL2 2 105382199 0.021 5.03E-05
cg07553761 TRIM59 3 161650671 0.016 6.12E-05
cg01588592 ETV3L 1 155335949 0.011 1.14E-04
cg11176990 LOC375196 2 39041037 0.014 1.54E-03
cg09499629 KLF14 7 130069676 0.018 1.54E-03
cg22158769 LOC375196 2 39041043 0.020 2.43E-03
cg18898125 NEFM 8 24826286 0.012 2.49E-03
cg21911021 ZIK1 19 62786823 0.020 3.07E-03
cg27217742 RGS12 4 3335078 0.013 3.07E-03
cg17737681 DLX1 2 172660382 0.015 3.29E-03
cg24079702 FHL2 2 105382203 0.015 5.99E-03
cg16219603 PENK 8 57523140 0.013 7.00E-03
cg23930856 TFAP2B 6 50919683 0.013 7.22E-03
cg11152943 TRAPPC9 8 141318170 0.013 7.57E-03