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Table 2 The top 20 hypomethylated a-CpGs in middle-aged individuals. The hypermethylated and hypomethylated a-CpGs are shown separately in Tables 1 and 2, respectively. The top-ranking hypomethylated a-CpGs were selected with the following criteria: 1) direction of the association based on the value of beta regression (denoted as ‘betareg’) estimate of age; 2) more than one hit identified per gene (q-value < 0.05 which corresponds to false discovery rate < 5 %) and 3) the top-ranking p-values. The full list of a-CpGs is shown in Additional file 3: Table S4. The q-value denotes the Benjamini-Hochberg-corrected p-value

From: Aging-associated DNA methylation changes in middle-aged individuals: the Young Finns study

ProbeID Gene name CHR Coordinate Betareg estimate of age q-value
cg00791074 MTHFD1L 6 151227862 -0.018 7.51E-04
cg18618815 COL1A1 17 45630323 -0.018 5.99E-03
cg14169886 PRDM16 1 3101709 -0.014 5.99E-03
cg01820374 LAG3 12 6752344 -0.014 9.24E-03
cg19421125 LAG3 12 6753117 -0.022 1.02E-02
cg14829066 NTRK3 15 86360145 -0.013 1.49E-02
cg03290281 C6orf195 6 2577606 -0.021 1.49E-02
cg05561193 DCLK2 4 151218492 -0.017 1.96E-02
cg20249566 NWD1 19 16691739 -0.024 1.97E-02
cg23928726 PEX10 1 2334858 -0.014 1.97E-02
cg20007894 SCAND3 6 28648421 -0.019 2.08E-02
cg16355231 PEX10 1 2334839 -0.019 2.14E-02
cg15058210 HDAC4 2 239861814 -0.018 2.16E-02
cg06030846 TMEM108 3 134581182 -0.011 2.16E-02
cg25994988 UBASH3B 11 122157592 -0.011 2.16E-02
cg18345924 NCAM2 21 21294102 -0.016 2.18E-02
cg00638021 COL1A1 17 45622061 -0.013 2.26E-02
cg19344626 NWD1 19 16691749 -0.024 2.36E-02
cg01288258 ITFG2 12 2792128 -0.011 2.41E-02
cg05221385 TAF10 11 6590080 -0.010 2.43E-02