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Table 3 Several GO process terms were enriched within genes with hypermethylated a-CpGs in the analysis with GOrilla [21, 43]. This table represents the main clusters of processes (53 redundant GO terms were filtered out of 73 terms using REViGO [44]). The full list of processes is shown in Additional file 2: Table S2

From: Aging-associated DNA methylation changes in middle-aged individuals: the Young Finns study

GO term Description of the process p-value (-log10)
GO:0048856 Anatomical structure development 10.9914
GO:0050794 Regulation of cellular process 8.9788
GO:0007389 Pattern specification process 8.2343
GO:0032502 Developmental process 8.2041
GO:0009893 Positive regulation of metabolic process 8.0511
GO:0044708 Single-organism behavior 7.5544
GO:0035108 Limb morphogenesis 7.5544
GO:0003002 Regionalization 7.3585
GO:0051239 Regulation of multicellular organismal process 7.301
GO:0006357 Regulation of transcription from RNA polymerase II promoter 7.2248
GO:0065007 Biological regulation 7.1675
GO:0007610 Behavior 7.08
GO:0048598 Embryonic morphogenesis 7.0778
GO:0048518 Positive regulation of biological process 6.8761
GO:0048519 Negative regulation of biological process 6.7122
GO:0008285 Negative regulation of cell proliferation 6.4921
GO:0048523 Negative regulation of cellular process 5.8827
GO:0010842 Retina layer formation 5.8041
GO:0051961 Negative regulation of nervous system development 5.7423
GO:0032774 RNA biosynthetic process 5.4225