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Table 2 Enriched biological processes commonly regulated by diet across adipose tissues

From: Molecular alterations induced by a high-fat high-fiber diet in porcine adipose tissues: variations according to the anatomical fat location

Functional annotation of responses to diet E scorea Nb DEG p-value HF vs. LF diet
GO:0019941 ~ modification-dependent protein catabolic process 4.31 34 <0.001 ↓: 31 ↑: 3
(GO:0006511 ~ ubiquitin-dependent protein catabolic process)   (21)   
GO:0046907 ~ intracellular transport 3.45 37 <0.001 ↓: 29 ↑: 8
(GO:0006886 ~ intracellular protein transport)   (26)   
GO:0006511 ~ ubiquitin-dependent protein catabolic process 2.76 21 <0.001 ↓: 20 ↑: 1
(GO:0010498 ~ proteasomal protein catabolic process)   (11)   
GO:0051186 ~ coenzyme metabolic process 1.72 11 0.003 ↓: 10 ↑: 1
GO:0033554 ~ cellular response to stress 1.58 28 <0.001 ↓: 18 ↑: 10
GO:0016310 ~ phosphorylation 1.42 31 0.017 ↓: 21 ↑: 10
GO:0019318 ~ hexose metabolic process 1.32 13 0.003 ↓: 13
(GO:0006006 ~ glucose metabolic process)   (11)   
(hsa00620:Pyruvate metabolism)   (7)   
(hsa00010:Glycolysis / Gluconeogenesis)   (5)   
GO:0017038 ~ protein import 1.25 9 0.017 ↓: 8 ↑: 1
GO:0009725 ~ response to hormone stimulus 0.99 16 0.042 ↓: 10 ↑: 6
GO:0010941 ~ regulation of cell death 0.94 33 0.007 ↓: 26 ↑: 7
GO:0000278 ~ mitotic cell cycle 0.66 18 0.010 ↓: 15 ↑: 3
  1. aThe most important genes in the common dietary-related responses across perirenal and subcutaneous adipose tissues and correlating with adiposity variations were considered to list enriched functional clusters. For each cluster based on gene ontology (GO) terms for biological processes and Genomes (KEGG) biological pathways, the enrichment (E) score, the number (Nb) of differentially-expressed genes (DEG) and associated p-value were provided. The direction of changes in gene expression levels by the HF diet was symbolized (↑: up-regulated; ↓: down-regulated) together with the number of unique genes concerned by each change