Fig. 7

Promoter elements associated with nitrogen limitation responsive genes have distance dependent effects. a Promoter regions of genes that encode up- and down-regulated proteins as well as a subset of β-oxidation specific down-regulated proteins are enriched for specific DNA motifs. b For each Y. lipolytica gene the distance to the nearest occurrence of each motif five prime of the transcription start site is determined and binned in 0.1 kb windows based on this distance. The average protein fold change values for each bin up to 1.5 kb from the transcription start site for Y. lipolytica grown in low (C/N = 150) versus high (C/N = 10) nitrogen are plotted. The grey span indicates the interquartile range. c The most strongly enriched gene ontology (GO) terms (p < 0.005) for genes with the given DNA motif present within 0.5 kb 5’ of their transcription start site