Fig. 2

Photoreceptor cell proliferation in the outer nuclear layer of normal and mutant retinas. a PHH3-labeling was used to identify mitotic cells, and b PCNA-labeling to identify cells undergoing proliferation and DNA repair. Normal retinas exhibited essentially no mitotic cells after 2 wks of age, while they were present in the ONL of the 3 diseased retinas. Mitotic cells were continually present throughout the first 14–20 wks of life in all 3 diseases, with the highest numbers observed in erd-mutants. The PCNA data for erd has been published previously (Fig. 3c in [18]). Data points are expressed as mean of triplicates ± SD. Note the difference in the scale of the y-axes between erd (on right) and normal, xlpra2 and rcd1 (left)