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Fig. 7 | BMC Genomics

Fig. 7

From: A novel comparative pattern analysis approach identifies chronic alcohol mediated dysregulation of transcriptomic dynamics during liver regeneration

Fig. 7

Analysis of a subset of the overall COMPACT matrix comprised of comparative patterns corresponding to differential regulation at 1 h in either dietary group. A set of 740 genes was distributed across the selected subset of patterns. a Differentially regulated genes that are novel or missing in the ethanol group are highlighted respectively in the middle column and row of the COMPACT matrix. Of the 93 genes with ethanol-specific response patterns, 36 showed transient upregulation, 20 showed transient down regulation, and 17 showed persistent up regulation until 6 h. Select key genes in these sets are indicated in D. Of the 130 genes with differential response that are missing in the ethanol group, 61 genes showed transient down regulation and 36 genes showed a transient up regulation at 1 h in the carbohydrate control group. b Comparative patterns corresponding to 1 h transient differential regulation in either dietary group are highlighted. The dominant patterns corresponded to gene sets with similar transient up or down regulation (sets f and h, respectively), as well as gene sets with ethanol-altered pattern of expression with shift towards differential regulation at 6 h (sets g and i). c Comparative patterns corresponding to 1 h and 6 h changes only (i.e., no differential regulation at 24 h) in at least one dietary group are highlighted. The dominant comparative pattern with 50 genes corresponded to similar direction of up regulation between the dietary groups at 1 h and 6 h. Other comparative patterns with more than 10 genes are also highlighted, corresponding to ethanol-altered differential regulation. d, e, f Heat map representation of gene expression patterns corresponding to the highlighted gene sets from panels a, b, and c, with select key genes indicated in each set

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