Table 1 Smokescreen genotyping array content
From: Smokescreen: a targeted genotyping array for addiction research
| Category | Markersa |
|---|---|
| 1014 addiction-related genes | |
| Tag SNPs (MAF ≥ 0.05) | 255862 |
| Exonic markers | 17632 |
| Genome-wide association markers | |
| Affymetrix’ Axiom® Biobank GWAS grid | 246038 |
| African (YRI) booster panel | 50000 |
| Fine-mapping of smoking related loci | |
| CHRNA5-CHRNA3-CHRNB4 (552 kb LD block) | 8913 |
| CYP2A6 (±20 kb) | 573 |
| CYP2B6 (±20 kb) | 1613 |
| High-value addiction markers | |
| NeuroSNP Project | 4994 |
| Pharmacogenetics of Nicotine Addiction Treatment (PNAT) SNP panels | 2271 |
| v1.0 Quit Success Score | 12058 |
| Literature search | 1329 |
| Comorbidity markers | |
| Lung Cancer | 3091 |
| Psychiatric disorders | 1200 |
| Tobacco smoke constituent update and metabolic phenotypes | 1907 |
| Pulmonary diseases and traits | 7945 |
| Cardiovascular diseases and traits | 2247 |
| General high-value markers | |
| Pharmacogenomic markers | 2030 |
| NHGRI GWAS Catalog | 7612 |
| eQTLs | 9736 |
| Loss-of-function markers | 4680 |
| Ancestry informative markers (AIMs) | 5545 |
| HLA/KIR | 8894 |
| Mitochondrial | 180 |
| Array Total | 646247 |