Detailed phenotyping identifies genes with pleiotropic effects on body composition

BMC Genomics

Table 3 Number of significant SNPs (P < 10⁻⁵) in reference population that were also significant in the validation population

P value in validation	No. of SNP	FDR%	%-same
multi-trait
0.0001	17	0.05	100
0.001	24	0.3	100
0.01	31	2.2	100
0.05	35	9.5	100
all	98		73
single-trait (PSWT)
0.0001	2	0.2	100
0.001	4	0.9	100
0.01	4	9.2	80
0.05	5	34.2	83
all	29		71
single-trait (LEGBONE)
0.0001	8	0.06	100
0.001	9	0.5	100
0.01	13	3.4	100
0.05	17	11.2	100
all	48		84
single-trait (DRESS%)
0.0001	2	0.19	100
0.001	3	1.23	100
0.01	7	4.67	100
0.05	9	16.4	90
all	31		78
single-trait (CCFAT)
0.0001
0.001	1	2.2	100
0.01	3	6.6	100
0.05	4	22.6	100
all	19		83

%-same = percentage of SNPs, which have an effect in the same direction in both validation and reference sets

ISSN: 1471-2164