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Table 4 Significant functional terms found for the genes displaying an increase in DNA methylation and expression at d7 relative to d1 in neonatal murine hearts

From: Changes in gene methylation patterns in neonatal murine hearts: Implications for the regenerative potential

GOID GOTerm p-value corrected with Bonferroni step down Associated Genes Found
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 8.09E-04 Cdh1, Cdh13, Cdh26, Esam, Igsf9, Pcdhga12, Scarf2, Umod
GO:0048705 skeletal system morphogenesis 1.43E-03 Alpl, Bmp4 , Chad, Hoxa3, Hoxa5, Hoxb5, Ltbp3, Osr1 , Tcf15, Tgfb3
GO:0009952 anterior/posterior pattern specification 5.37E-03 Bmp4 , Hoxa3, Hoxa5, Hoxb5, Med12, Meox1, Osr1 , Tcf15, Zic3
GO:0031032 actomyosin structure organization 1.01E-02 Ankrd23, Asap3, Lmod2 , Myh7b, Mypn , Neb , Tpm1
GO:0048771 tissue remodelling 1.68E-02 Clec10a, Dll4 , Hoxa3, Ltbp3, Nol3, Pml, Spp2
GO:0055002 striated muscle cell development 3.74E-02 Ankrd23, Bmp4, Lmod2, Mypn, Neb , P2rx2
GO:0045064 T-helper 2 cell differentiation 8.02E-03 Bcl3, Hlx, Irf1
GO:0005520 insulin-like growth factor binding 3.24E-02 Cyr61, Htra4, Igfbp6
  1. As revealed by ClueGo gene ontology analysis, a group of 215 genes showing a gain in DNA methylation and a minimum 1.5-fold increase in expression level was significantly enriched in developmental genes. Remarkable genes reported to participate in heart functions a development are distinguished by bold font. (The 215 genes are are listed in Additional file 1: F1 quadrant of Fig. 8)