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Table 4 Significant functional terms found for the genes displaying an increase in DNA methylation and expression at d7 relative to d1 in neonatal murine hearts

From: Changes in gene methylation patterns in neonatal murine hearts: Implications for the regenerative potential

GOID

GOTerm

p-value corrected with Bonferroni step down

Associated Genes Found

GO:0098742

cell-cell adhesion via plasma-membrane adhesion molecules

8.09E-04

Cdh1, Cdh13, Cdh26, Esam, Igsf9, Pcdhga12, Scarf2, Umod

GO:0048705

skeletal system morphogenesis

1.43E-03

Alpl, Bmp4 , Chad, Hoxa3, Hoxa5, Hoxb5, Ltbp3, Osr1 , Tcf15, Tgfb3

GO:0009952

anterior/posterior pattern specification

5.37E-03

Bmp4 , Hoxa3, Hoxa5, Hoxb5, Med12, Meox1, Osr1 , Tcf15, Zic3

GO:0031032

actomyosin structure organization

1.01E-02

Ankrd23, Asap3, Lmod2 , Myh7b, Mypn , Neb , Tpm1

GO:0048771

tissue remodelling

1.68E-02

Clec10a, Dll4 , Hoxa3, Ltbp3, Nol3, Pml, Spp2

GO:0055002

striated muscle cell development

3.74E-02

Ankrd23, Bmp4, Lmod2, Mypn, Neb , P2rx2

GO:0045064

T-helper 2 cell differentiation

8.02E-03

Bcl3, Hlx, Irf1

GO:0005520

insulin-like growth factor binding

3.24E-02

Cyr61, Htra4, Igfbp6

  1. As revealed by ClueGo gene ontology analysis, a group of 215 genes showing a gain in DNA methylation and a minimum 1.5-fold increase in expression level was significantly enriched in developmental genes. Remarkable genes reported to participate in heart functions a development are distinguished by bold font. (The 215 genes are are listed in Additional file 1: F1 quadrant of Fig. 8)