Fig. 5

Preferred motif pair arrangements. For all 18 motif pairs with non-random arrangement distribution, relative frequencies were computed; i.e., counts per arrangement divided by the total count for all eight possible arrangements followed by a summation for each arrangement type across all 18 motifs. Plotted are the resulting summed-up relative frequencies for the two possible motif orders with regard to sequence position and orientation where “+” denotes forward, and “-“reverse-complement orientation. Preferences for co-directionally aligned orientations, i.e., both in forward or both in reverse-complement orientation are evident. The central plot entitled “same motif” shows the relative counts for same-motifs only (Note that the order does not matter and the associated frequencies are identical.), whereas the plot “different motifs” shows the data for two different motifs considered a pair