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Fig. 4 | BMC Genomics

Fig. 4

From: Differential responsiveness of Holstein and Angus dermal fibroblasts to LPS challenge occurs without major differences in the methylome

Fig. 4

Role of DNA methylation on gene expression and differential methylation levels due to genomic location. As there were no significant effects of breed on the correlations between genomic location of DNA methylation and subsequent gene expression, data was combined for the 4 Holstein and 4 Angus cultures in this analysis. Scatter plots show the relation between gene expression at 8 h post-LPS treatment and levels of DNA methylation at the gene’s promoter (a) or gene body (b) Gene expression levels (RNA-Seq) and DNA methylation (MIRA-Seq) were normalized to gene size and presented as RPKM. c The average methylation levels of combined Holstein and Angus MIRA-Seq libraries based upon genomic region. Lettering denotes differential methylation levels as measured by a one-way ANOVA with Bonferonni post-test (p < 0.05). All values are mean ± SEM

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BMC Genomics

ISSN: 1471-2164

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