Table 1 Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathways that were significantly over-represented in hepatic tissue in restricted fed animals compared with ad libitum control animals following a period of dietary restriction at the end of Period 1

Metabolic pathways

<0.0001

Ribosome

<0.0001

Steroid hormone biosynthesis

0.0007

Arginine and proline metabolism

0.0013

Glycine, serine and threonine metabolism

0.0029

Citrate cycle

0.003

Starch and sucrose metabolism

0.0035

PPAR¹ signalling pathway

0.0085

Protein processing in endoplasmic reticulum

0.010

Tryptophan metabolism

0.0212

MAPK signalling pathway

0.028

Valine, leucine and isoleucine degradation

0.029

Tyrosine metabolism

0.036

Insulin signalling pathway

0.0498