Fig. 2From: Long genes and genes with multiple splice variants are enriched in pathways linked to cancer and other multigenic diseasesGenes in the pathways linked to multigenic diseases are, on average, longer and have more splice variants. a Distribution of Ltr in each of the 186 KEGG pathways, in the ascending order of the Ltr median values. The horizontal dashed line in (a) denotes the 200Â k-nt threshold for a transcript length, known to be relevant in defining the topoisomerase-dependent transcription of the genes that are longer [7]. Ltr values are calculated for each unique gene, taking the length of the longest transcript, prior to splicing. b The fraction of genes (in an ascending order) with number of transcripts greater than 3 in each of the 186 KEGG pathways. The names of the KEGG pathways, ordered in the way corresponding to the indices in x-axes, can be found in Notes S1 and S2 in Additional file 1 for the plots (a) and (b). The cancer-linked pathways are highlighted in red, as opposed to blue for the rest. Some pathways from the rest, still related to cancer or other multigenic diseases are indicated with arrowsBack to article page