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Table 1 The KEGG pathway enrichment analysis for the genes with number of transcripts greater than 3

From: Long genes and genes with multiple splice variants are enriched in pathways linked to cancer and other multigenic diseases

Genes with Ntr > 3

KEGG pathway

Number of genes

p EASE score

Calcium signaling pathway (b,c)

40

8.43 10−4

Pathways in cancer (a)

64

1.54 10−3

p53 signaling pathway (a)

19

2.93 10−3

MAPK signaling pathway (a)

51

7.68 10−3

Apoptosis (a)

21

9.85 10−3

Acute myeloid leukemia (a)

15

1.88 10−2

ErbB signaling pathway

20

2.00 10−2

NOD-like receptor signaling pathway

15

3.25 10−2

Thyroid cancer (a)

9

3.29 10−2

Progesterone-mediated oocyte maturation

19

3.44 10−2

Hematopoietic cell lineage

19

3.44 10−2

Neurotrophin signaling pathway

25

3.87 10−2

Wnt signaling pathway

29

4.45 10−2

Prostate cancer (a)

19

4.65 10−2

Adherens junction

17

4.71 10−2

  1. The significantly enriched KEGG pathways are revealed via DAVID gene functional annotation server, taking Homo sapiens as a correction background. The p EASE significance scores for the enrichment are shown along with the number of hit genes. The notations in the brackets mark the pathways linked to cancer (a), neurological (b) and cardiological (c) conditions. The full list of genes that appear in each enriched pathway can be found in Additional file 3