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Table 1 The KEGG pathway enrichment analysis for the genes with number of transcripts greater than 3

From: Long genes and genes with multiple splice variants are enriched in pathways linked to cancer and other multigenic diseases

Genes with Ntr > 3
KEGG pathway Number of genes p EASE score
Calcium signaling pathway (b,c) 40 8.43 10−4
Pathways in cancer (a) 64 1.54 10−3
p53 signaling pathway (a) 19 2.93 10−3
MAPK signaling pathway (a) 51 7.68 10−3
Apoptosis (a) 21 9.85 10−3
Acute myeloid leukemia (a) 15 1.88 10−2
ErbB signaling pathway 20 2.00 10−2
NOD-like receptor signaling pathway 15 3.25 10−2
Thyroid cancer (a) 9 3.29 10−2
Progesterone-mediated oocyte maturation 19 3.44 10−2
Hematopoietic cell lineage 19 3.44 10−2
Neurotrophin signaling pathway 25 3.87 10−2
Wnt signaling pathway 29 4.45 10−2
Prostate cancer (a) 19 4.65 10−2
Adherens junction 17 4.71 10−2
  1. The significantly enriched KEGG pathways are revealed via DAVID gene functional annotation server, taking Homo sapiens as a correction background. The p EASE significance scores for the enrichment are shown along with the number of hit genes. The notations in the brackets mark the pathways linked to cancer (a), neurological (b) and cardiological (c) conditions. The full list of genes that appear in each enriched pathway can be found in Additional file 3