Fig. 3

The human 4TM Enzyme class. The figure displays the 45 proteins identified with an EC number that belong to the Enzyme class. The enzymes are divided into five groups which correspond to the type of chemical reaction that they catalyze. Uniprot cross-references the ENZYME nomenclature database and IntEnz (Integrated relational Enzyme database) to obtain the EC number associated with a protein. The single protein classified as a drug target as well as the drug indications are displayed. The drug target and drug indications were identified through an updated dataset of all current targeted and potential proteins and genes involved in drug studies or experimentation. Some of the most common gene-disease associations are also shown for each of the subgroups in the Enzyme class. Three different resources were used to identify gene-disease associations: the Online Mendelian Inheritance in Man (OMIM) database; the Functional Disease Ontology (FunDO) resource; and the Jensen Lab Diseases database (see Methods for details). Proteins that are involved in enzymatic activity but do not have an associated EC number are not included in this class, but rather in a subgroup of the Miscellaneous proteins. The number in parenthesis represents the number of proteins that have been identified