Fig. 5

Upstream regulators indicated by IPA potentially affecting expression of DEG in the hypothalamus of 21-day old female progeny undernourished during early development. a estrogen receptor 1 and 2 (ESR1 and ESR2), b Leptin (LEP), and c androgen receptor (AR) were selected for detailed presentation. Networks are displayed graphically as nodes (genes/genes products) and edges (biological relationship between nodes). The node color intensity indicates the fold-change expression of DEG; with red representing up-regulation and green down-regulation in CON vs. LUN animals. The fold change value for individual DEG is indicated under each node. The shapes of nodes indicate the functional class of the gene product and the lines indicate the type of interaction, explained in the legend. All connections were integrated into the computationally generated networks on the basis of the evidence stored in the IPA knowledge memory base indicating relevance for these networks