Fig. 4

Chromosome 6 interaction maps displayed for two datasets presenting similar number of filtered PETs but different global QC scores. The illustrated HiC (GSM1055801) and in situ HiC (GSM1551563) datasets comprise about 120 million filtered PETs, nevertheless their global QC scores are different (higher quality for in situ than for the classical HiC assay). In both cases, large genome interaction views (top panels: 10 million bp), as well as closer views (5 million bp) clearly demonstrate the presence of more clearly defined topological domains in the in situ HiC dataset. Note that for the close-ups, both the PET count displays from the original datasets, as well as PET count dispersion displays (dPETs) of the random sub-samplings clearly illustrate the differences in quality of the interaction patterns