Table 2 Gene onthology of the TM/C DE genes
Gene name | Molecular function | Fold Change |
|---|---|---|
Energy metabolism | ||
MRPL28 | Mitochondrial ribosomal protein encoded by the nucleus which helps in protein synthesis within the mitochondrion | 0.78 |
COQ6 | Monooxygenase required for the biosynthesis of coenzyme Q10. | 0.84 |
MCAT | Enzyme which catalyzes the transfer of a malonyl group from malonyl-CoA to the mitochondrial acyl carrier protein. | 0.85 |
TBL1X | Corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. | 1.28 |
ACP6 | Phosphatase which regulates lipid metabolism in mitochondria. | 0.81 |
CYP39A1 | Monooxygenase, which catalyzes many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. | 0.84 |
Cell proliferation and vascularization pathway | ||
BTC | Ligand for the EGF receptor, regulation cell growth and differentiation. | 1.22 |
ABHD2 | Protein specifically expressed in mouse vascular muscle cells and not in skeletal muscle cells. | 1.24 |
EPS15 | Protein involved in EGFR pathway. | 1.24 |
Muscle growth | ||
MBNL2 | C3H-type zinc finger protein that modulates alternative splicing of pre-mRNA, involved in the physiopathology of muscle dystrophy. | 1.25 |
RBM20 | RNA binding protein involved in familial dilated cardiomyopathy and is involved in alternative splicing of TTN. | 1.37 |
TTN | Protein of striated muscle. | 1.53 |
OBSCN | Proteins that include titin and nebulin, and may have a role in the organization of myofibrils during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils. | 1.50 |
ADHFE1 | Hydroxyacid-oxoacid transhydrogenase which is responsible for the oxidation of 4-hydroxybutyrate in mammalian tissues; involved in increased muscle mass in horses. | 1.58 |
SLC25A33 | Pyrimidine Nucleotide Carrier which is associated with muscle wasting. | 0.82 |
B-G | Leukocyte antigen. | 1.59 |
Receptor for pain | ||
P2RX4 | Purinoreceptor for ATP-gated ion channel, involved in pain reception in mouse. | 0.78 |
Ion Channel | ||
SCN5A | Integral membrane protein and voltage-gated sodium channel subunit. | 1.31 |
DNA repair | ||
EME2 | Involved in repairing DNA damage and maintaining genomic stability. | 0.65 |