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Table 2 Gene onthology of the TM/C DE genes

From: Thermal manipulation of the chicken embryo triggers differential gene expression in response to a later heat challenge

Gene name Molecular function Fold Change
Energy metabolism
MRPL28 Mitochondrial ribosomal protein encoded by the nucleus which helps in protein synthesis within the mitochondrion 0.78
COQ6 Monooxygenase required for the biosynthesis of coenzyme Q10. 0.84
MCAT Enzyme which catalyzes the transfer of a malonyl group from malonyl-CoA to the mitochondrial acyl carrier protein. 0.85
TBL1X Corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. 1.28
ACP6 Phosphatase which regulates lipid metabolism in mitochondria. 0.81
CYP39A1 Monooxygenase, which catalyzes many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. 0.84
Cell proliferation and vascularization pathway
BTC Ligand for the EGF receptor, regulation cell growth and differentiation. 1.22
ABHD2 Protein specifically expressed in mouse vascular muscle cells and not in skeletal muscle cells. 1.24
EPS15 Protein involved in EGFR pathway. 1.24
Muscle growth
MBNL2 C3H-type zinc finger protein that modulates alternative splicing of pre-mRNA, involved in the physiopathology of muscle dystrophy. 1.25
RBM20 RNA binding protein involved in familial dilated cardiomyopathy and is involved in alternative splicing of TTN. 1.37
TTN Protein of striated muscle. 1.53
OBSCN Proteins that include titin and nebulin, and may have a role in the organization of myofibrils during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils. 1.50
ADHFE1 Hydroxyacid-oxoacid transhydrogenase which is responsible for the oxidation of 4-hydroxybutyrate in mammalian tissues; involved in increased muscle mass in horses. 1.58
SLC25A33 Pyrimidine Nucleotide Carrier which is associated with muscle wasting. 0.82
B-G Leukocyte antigen. 1.59
Receptor for pain  
P2RX4 Purinoreceptor for ATP-gated ion channel, involved in pain reception in mouse. 0.78
Ion Channel   
SCN5A Integral membrane protein and voltage-gated sodium channel subunit. 1.31
DNA repair   
EME2 Involved in repairing DNA damage and maintaining genomic stability. 0.65
  1. MRPL28, Mitochondrial ribosomal protein L28; COQ6, Coenzyme Q6 homolog, monooxygenase; MCAT, Malonyl CoA:ACP acyltransferase; TBL1X, Transducin (beta)-like 1X-linked; ACP6, acid phosphatase 6; CYP39A1, Cytochrome P450, family 39, subfamily A, polypeptide 1; BTC, Betacellulin, ABHD2, Abhydrolase domain containing 2; EPS15, Epidermal growth factor receptor pathway substrate 15; MBNL2, Muscleblind-like 2 Drosophila; RBM20, RNA binding motif protein 20; TTN, Titin; OBSCN, Obscurin; ADHFE1, Alcohol dehydrogenase, iron containing, 1; SLC25A33, Carrier family 25, member 3; B-G, V-region-like B-G antigen-like; P2RX4, purinergic receptor P2X, ligand-4; SCN5A, sodium channel, voltage-gated, type V, alpha subunit, transcript variant 4; EME2, Essential Meiotic endonuclease 2 homolog 1