Fig. 5

DNA damage alters the ATF3-binding landscape for transcriptional regulation. a Venn diagram showing overlap of ATF3-binding peaks between the basal (ATF3-WT) and the CPT-treated (ATF3-CPT) conditions. b Heatmaps and intensity plots showing alterations in the ATF3-binding profile caused by DNA damage. c Intensity plots showing different enrichments of ATF3, p300, and histone markers between CPT-induced and decreased peaks. d Distribution of ATF3-binding sites under basal (ATF3-Ctrl) and stressed (ATF3-CPT) conditions. e Venn diagram showing overlaps of ATF3 peaks and p300 peaks under the CPT-treatment condition. f Heatmaps showing CPT-regulated genes. g Heatmaps of ATF3-binding sites associated with CPT-regulated genes showing that ATF3 was pre-loaded on most of these genes before stress. h Intensity plot showing that ATF3 binding to CPT-regulated genes was increased by the CPT treatment. i Heatmap showing ATF3-regulated genes under the DNA damage condition were pre-bound by ATF3. j Intensity plot showing that DNA damage increased ATF3 binding to ATF3-regulated genes