Fig. 8
From: Seasonal immunoregulation in a naturally-occurring vertebrate
Seasonal bias in toll-like receptor (TLR) signalling pathway. a Differential winter-summer gene expression in pathway members (based on modified KEGG TLR signalling pathway), demonstrating winter bias in some cases and summer bias in others. Categorization of differential expression is based on overall significance levels in general linear models (LMs) with explanatory terms for site, sex and length (less stringent criteria than used in initial genome-wide analyses). b Principal co-ordinates (PCO) ordination of gene expression in all pathway members, revealing considerable winter-summer discrimination; scatter of individual points against the 3 major axes (PCO-1-3) and concentration ellipsoids containing 50 % of points