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Table 1 Results of Bivariate GWAS for C-Reactive Protein and LDL-Cholesterol Levels

From: Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation

SNP Chromosome Position Effect Allele C-reactive protein LDL-cholesterol Pleiotropy significance Gene
Beta P-value Beta P-value
rs646776 1 109620053 T −0.018 0.02 0.171 4.5 × 10−169 4.3 × 10−170 CELSR2
rs661955 1 232909479 C −0.021 1.7 × 10−3 0.034 1.2 × 10−10 3.2 × 10−12 IRF2BP2
rs3817588 2 27584716 T 0.053 1.8 × 10−10 0.024 4.2 × 10−4 6.4 × 10−12 GCKR
rs11887534 2 43919751 C −0.049 2.5 × 10−4 −0.134 1.1 × 10−31 9.0 × 10−33 ABCG8
rs12711751 2 113554236 T −0.044 1.6 × 10−10 0.014 4.8 × 10−3 1.2 × 10−11 IL1F10
rs4703642 5 74297918 A 0.018 3.0 × 10−3 −0.031 3.1 × 10−10 1.5 × 10−11 GCNT4
rs9275292 6 32771267 A 0.022 3.6 × 10−4 0.023 1.1 × 10−5 3.3 × 10−8 HLA-DQB1
rs3822857 6 116420624 C −0.032 2.7 × 10−6 −0.030 2.3 × 10−7 7.6 × 10−12 FRK
rs9987289 8 9220768 A −0.079 2.1 × 10−12 −0.071 2.0 × 10−14 2.3 × 10−24 PPP1R3B
rs8180991 8 126569532 C −0.026 9.0 × 10−4 −0.041 8.0 × 10−10 5.1 × 10−11 TRIB1
rs174574 11 61356918 A −0.027 1.7 × 10−3 −0.050 1.1 × 10−8 7.8 × 10−10 FADS2
rs11220463 11 125753421 A 0.032 2.8 × 10−3 −0.070 1.3 × 10−15 5.8 × 10−17 ST3GAL4
rs10744775 12 110580598 T 0.021 4.0 × 10−3 −0.030 5.3 × 10−7 3.1 × 10−8 BRAP
rs2285810 12 111183923 T 0.019 6.8 × 10−3 −0.030 8.3 × 10−8 8.3 × 10−9 C12orf51
rs1183910 12 119905190 A −0.151 4.6 × 10−113 0.042 5.8 × 10−15 5.6 × 10−128 HNF1A
rs340005 15 58665322 A 0.044 3.2 × 10−11 −0.015 3.4 × 10−3 1.7 × 10−12 RORA
rs1529711 19 10884434 T 0.030 8.4 × 10−4 0.037 1.5 × 10−6 1.5 × 10−8 CARM1/LDLR
rs2228603 19 19190924 T 0.036 2.9 × 10−3 −0.089 1.4 × 10−19 6.5 × 10−21 NCAN
rs4420638 19 50114786 A 0.240 1.0 × 10−129 −0.215 8.7 × 10−147 1.2 × 10−283 APOC1
rs2287921 19 53920084 T −0.019 3.6 × 10−3 −0.026 3.4 × 10−7 2.8 × 10−8 RASIP1
rs1800961 20 42475778 T −0.120 2.4 × 10−11 −0.070 2.4 × 10−5 3.8 × 10−14 HNF4A
  1. Abbreviations: SNP single nucleotide polymorphism
  2. For both CRP and the lipid phenotype, the effect estimates are according to the original GWAS
  3. Chromosome and position are in NCBI genome build 36
  4. Beta coefficient for CRP represents 1-unit change in the natural log–transformed CRP (mg/L) per copy increment in the coded allele
  5. Beta coefficient for LDL-cholesterol represents 1-unit change in the standardized LDL-cholesterol levels per copy increment in the coded allele