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Table 1 Results of Bivariate GWAS for C-Reactive Protein and LDL-Cholesterol Levels

From: Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation

SNP

Chromosome

Position

Effect Allele

C-reactive protein

LDL-cholesterol

Pleiotropy significance

Gene

Beta

P-value

Beta

P-value

rs646776

1

109620053

T

−0.018

0.02

0.171

4.5 × 10−169

4.3 × 10−170

CELSR2

rs661955

1

232909479

C

−0.021

1.7 × 10−3

0.034

1.2 × 10−10

3.2 × 10−12

IRF2BP2

rs3817588

2

27584716

T

0.053

1.8 × 10−10

0.024

4.2 × 10−4

6.4 × 10−12

GCKR

rs11887534

2

43919751

C

−0.049

2.5 × 10−4

−0.134

1.1 × 10−31

9.0 × 10−33

ABCG8

rs12711751

2

113554236

T

−0.044

1.6 × 10−10

0.014

4.8 × 10−3

1.2 × 10−11

IL1F10

rs4703642

5

74297918

A

0.018

3.0 × 10−3

−0.031

3.1 × 10−10

1.5 × 10−11

GCNT4

rs9275292

6

32771267

A

0.022

3.6 × 10−4

0.023

1.1 × 10−5

3.3 × 10−8

HLA-DQB1

rs3822857

6

116420624

C

−0.032

2.7 × 10−6

−0.030

2.3 × 10−7

7.6 × 10−12

FRK

rs9987289

8

9220768

A

−0.079

2.1 × 10−12

−0.071

2.0 × 10−14

2.3 × 10−24

PPP1R3B

rs8180991

8

126569532

C

−0.026

9.0 × 10−4

−0.041

8.0 × 10−10

5.1 × 10−11

TRIB1

rs174574

11

61356918

A

−0.027

1.7 × 10−3

−0.050

1.1 × 10−8

7.8 × 10−10

FADS2

rs11220463

11

125753421

A

0.032

2.8 × 10−3

−0.070

1.3 × 10−15

5.8 × 10−17

ST3GAL4

rs10744775

12

110580598

T

0.021

4.0 × 10−3

−0.030

5.3 × 10−7

3.1 × 10−8

BRAP

rs2285810

12

111183923

T

0.019

6.8 × 10−3

−0.030

8.3 × 10−8

8.3 × 10−9

C12orf51

rs1183910

12

119905190

A

−0.151

4.6 × 10−113

0.042

5.8 × 10−15

5.6 × 10−128

HNF1A

rs340005

15

58665322

A

0.044

3.2 × 10−11

−0.015

3.4 × 10−3

1.7 × 10−12

RORA

rs1529711

19

10884434

T

0.030

8.4 × 10−4

0.037

1.5 × 10−6

1.5 × 10−8

CARM1/LDLR

rs2228603

19

19190924

T

0.036

2.9 × 10−3

−0.089

1.4 × 10−19

6.5 × 10−21

NCAN

rs4420638

19

50114786

A

0.240

1.0 × 10−129

−0.215

8.7 × 10−147

1.2 × 10−283

APOC1

rs2287921

19

53920084

T

−0.019

3.6 × 10−3

−0.026

3.4 × 10−7

2.8 × 10−8

RASIP1

rs1800961

20

42475778

T

−0.120

2.4 × 10−11

−0.070

2.4 × 10−5

3.8 × 10−14

HNF4A

  1. Abbreviations: SNP single nucleotide polymorphism
  2. For both CRP and the lipid phenotype, the effect estimates are according to the original GWAS
  3. Chromosome and position are in NCBI genome build 36
  4. Beta coefficient for CRP represents 1-unit change in the natural log–transformed CRP (mg/L) per copy increment in the coded allele
  5. Beta coefficient for LDL-cholesterol represents 1-unit change in the standardized LDL-cholesterol levels per copy increment in the coded allele
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BMC Genomics

ISSN: 1471-2164

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