Table 3 Results of Bivariate GWAS Analyses for C-Reactive Protein and Triglycerides Levels
SNP | Chromosome | Position | Effect Allele | C-reactive protein | Triglycerides | Pleiotropy significance | Gene | ||
|---|---|---|---|---|---|---|---|---|---|
Beta | P-value | Beta | P-value | ||||||
rs4660808 | 1 | 39791096 | T | 0.046 | 8.6 × 10−10 | 0.028 | 3.1 × 10−7 | 2.2 × 10−13 | PABPC4 |
rs11208722 | 1 | 65943589 | A | −0.083 | 1.2 × 10−32 | 0.012 | 0.02 | 8.1 × 10−36 | LEPR |
rs1127311 | 1 | 152823287 | A | −0.031 | 9.3 × 10−7 | 0.012 | 5.5 × 10−3 | 6.4 × 10−9 | ADAR |
rs12755606 | 1 | 157936960 | C | −0.153 | 3.0 × 10−112 | 0.012 | 0.01 | 4.0 × 10−120 | CRP |
rs1260326 | 2 | 27584444 | T | 0.089 | 1.7 × 10−42 | 0.116 | 5.7 × 10−133 | 4.4 × 10−151 | GCKR |
rs13409360 | 2 | 113554573 | A | 0.048 | 1.3 × 10−12 | −0.013 | 8.6 × 10−3 | 5.3 × 10−15 | IL1F10 |
rs645040 | 3 | 137409312 | T | −0.023 | 2.5 × 10−3 | 0.030 | 2.5 × 10−8 | 4.6 × 10−11 | MSL2L1 |
rs2524163 | 6 | 31367558 | T | 0.025 | 1.5 × 10−4 | 0.027 | 1.7 × 10−8 | 7.9 × 10−10 | HLA-C |
rs9987289 | 8 | 9220768 | A | −0.079 | 2.1 × 10−12 | 0.020 | 0.02 | 2.9 × 10−14 | PPP1R3B |
rs10435719 | 8 | 11814313 | T | 0.026 | 7.6 × 10−5 | −0.022 | 4.1 × 10−6 | 2.0 × 10−10 | CTSB |
rs1441759 | 8 | 19909843 | C | 0.11 | 3.3 × 10−4 | 0.125 | 2.1 × 10−8 | 2.0 × 10−9 | LPL |
rs10832027 | 11 | 13313759 | A | 0.032 | 8.5 × 10−7 | 0.020 | 1.1 × 10−4 | 9.4 × 10−9 | ARNTL |
rs174546 | 11 | 61326406 | T | −0.017 | 0.01 | 0.048 | 5.4 × 10−24 | 5.2 × 10−27 | FADS1 |
rs2686555 | 12 | 119579555 | A | −0.059 | 1.7 × 10−19 | 0.010 | 0.03 | 1.6 × 10−21 | CABP1 |
rs11508026 | 16 | 55556829 | T | 0.014 | 0.03 | −0.038 | 1.3 × 10−12 | 3.1 × 10−14 | CETP |
rs571312 | 18 | 55990749 | A | 0.033 | 3.5 × 10−5 | 0.026 | 1.2 × 10−5 | 2.8 × 10−8 | MC4R |
rs10401969 | 19 | 19268718 | T | −0.031 | 0.02 | 0.112 | 1.6 × 10−29 | 1.6 × 10−32 | SF4 |
rs1688043 | 19 | 40245181 | T | −0.038 | 2.4 × 10−3 | 0.037 | 1.2 × 10−5 | 4.1 × 10−8 | HPN |
rs4420638 | 19 | 50114786 | A | 0.24 | 1.0 × 10−129 | −0.068 | 5.4 × 10−22 | 1.7 × 10−171 | APOC1 |
rs4465830 | 20 | 44018827 | A | 0.036 | 7.0 × 10−6 | −0.050 | 2.0 × 10−17 | 2.0 × 10−24 | ZNF335/PLTP |
rs2277844 | 22 | 36907461 | A | −0.018 | 5.7 × 10−3 | 0.025 | 1.5 × 10−7 | 9.2 × 10−10 | PLA2G6 |