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Table 3 Results of Bivariate GWAS Analyses for C-Reactive Protein and Triglycerides Levels

From: Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation

SNP Chromosome Position Effect Allele C-reactive protein Triglycerides Pleiotropy significance Gene
Beta P-value Beta P-value
rs4660808 1 39791096 T 0.046 8.6 × 10−10 0.028 3.1 × 10−7 2.2 × 10−13 PABPC4
rs11208722 1 65943589 A −0.083 1.2 × 10−32 0.012 0.02 8.1 × 10−36 LEPR
rs1127311 1 152823287 A −0.031 9.3 × 10−7 0.012 5.5 × 10−3 6.4 × 10−9 ADAR
rs12755606 1 157936960 C −0.153 3.0 × 10−112 0.012 0.01 4.0 × 10−120 CRP
rs1260326 2 27584444 T 0.089 1.7 × 10−42 0.116 5.7 × 10−133 4.4 × 10−151 GCKR
rs13409360 2 113554573 A 0.048 1.3 × 10−12 −0.013 8.6 × 10−3 5.3 × 10−15 IL1F10
rs645040 3 137409312 T −0.023 2.5 × 10−3 0.030 2.5 × 10−8 4.6 × 10−11 MSL2L1
rs2524163 6 31367558 T 0.025 1.5 × 10−4 0.027 1.7 × 10−8 7.9 × 10−10 HLA-C
rs9987289 8 9220768 A −0.079 2.1 × 10−12 0.020 0.02 2.9 × 10−14 PPP1R3B
rs10435719 8 11814313 T 0.026 7.6 × 10−5 −0.022 4.1 × 10−6 2.0 × 10−10 CTSB
rs1441759 8 19909843 C 0.11 3.3 × 10−4 0.125 2.1 × 10−8 2.0 × 10−9 LPL
rs10832027 11 13313759 A 0.032 8.5 × 10−7 0.020 1.1 × 10−4 9.4 × 10−9 ARNTL
rs174546 11 61326406 T −0.017 0.01 0.048 5.4 × 10−24 5.2 × 10−27 FADS1
rs2686555 12 119579555 A −0.059 1.7 × 10−19 0.010 0.03 1.6 × 10−21 CABP1
rs11508026 16 55556829 T 0.014 0.03 −0.038 1.3 × 10−12 3.1 × 10−14 CETP
rs571312 18 55990749 A 0.033 3.5 × 10−5 0.026 1.2 × 10−5 2.8 × 10−8 MC4R
rs10401969 19 19268718 T −0.031 0.02 0.112 1.6 × 10−29 1.6 × 10−32 SF4
rs1688043 19 40245181 T −0.038 2.4 × 10−3 0.037 1.2 × 10−5 4.1 × 10−8 HPN
rs4420638 19 50114786 A 0.24 1.0 × 10−129 −0.068 5.4 × 10−22 1.7 × 10−171 APOC1
rs4465830 20 44018827 A 0.036 7.0 × 10−6 −0.050 2.0 × 10−17 2.0 × 10−24 ZNF335/PLTP
rs2277844 22 36907461 A −0.018 5.7 × 10−3 0.025 1.5 × 10−7 9.2 × 10−10 PLA2G6
  1. Abbreviations: SNP single nucleotide polymorphism
  2. For both CRP and the lipid phenotype, the effect estimates are according to the original GWAS
  3. Chromosome and position are in NCBI genome build 36
  4. β coefficient for CRP represents 1-unit change in the natural log–transformed CRP (mg/L) per copy increment in the coded allele
  5. Beta coefficient for triglycerides represents 1-unit change in the standardized triglyceride levels per copy increment in the coded allele