Fig. 1

Gene expression alterations induced by NMDA receptor antagonists in mouse hippocampus and striatum. Microarray results are shown as a heat map and include genes with a genome-wide significance from three-way ANOVA for the drug factor (FDR < 0.01 and log₂ fold change > 0.5 at least at one time-point in any substance). Colored rectangles represent transcript abundance 1, 2, 4 and 8 h after injection of the drug indicated above - ketamine (KET), memantine (MEM) and PCP. Intensity of the color is proportional to the standardized values (between −3 and 3) from each microarray, as displayed on the bar below the heat map image. Hierarchical clustering was performed using Euclidean distance. Major clusters of drug-responsive genes are arbitrarily described as ‘C1’, ‘C2’ and ‘C3’. The over-representation of the pathways was found statistically significant with *p < 0.05. Genes involved in the indicated pathways, but displaying different transcription patterns were marked with grey color