A loss of function variant in CASP7 protects against Alzheimer’s disease in homozygous APOE ε4 allele carriers

BMC Genomics

Table 2 Association between CASP7 rs10553596 and AD/dementia status in APOE ε4 allele carriers (A), and non-APOEε 4 allele carriers (B), stratified by ethnicity in Mount Sinai Biobank

A. Carriers: Overall P-value = 0.031, OR = 0.56 (95 % CI 0.00–0.94)
Ethnicity	Phenotype	Ref-Ref	Alt-*	P-value	Odds Ratio
European	Controls	137	141	0.25	0.49
European	AD/dementia	6	3	0.25	0.49
African	Controls	68	145	0.19	0.54
African	AD/dementia	7	8	0.19	0.54
Hispanic	Controls	155	146	0.12	0.56
Hispanic	AD/dementia	17	9	0.12	0.56
B. Non-Carriers: Overall P-value = 0.060, OR = 0.77 (95 % CI 0.00–1.01)
Ethnicity	Phenotype	Ref-Ref	Alt-*	P-value	Odds Ratio
European	Controls	588	637	0.43	0.83
European	AD/dementia	10	9	0.43	0.83
African	Control	233	453	0.24	0.74
African	AD/dementia	14	20	0.24	0.74
Hispanic	Control	867	731	0.17	0.80
Hispanic	AD/dementia	62	42	0.17	0.80

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