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Table 2 Association between CASP7 rs10553596 and AD/dementia status in APOE ε4 allele carriers (A), and non-APOEε 4 allele carriers (B), stratified by ethnicity in Mount Sinai Biobank

From: A loss of function variant in CASP7 protects against Alzheimer’s disease in homozygous APOE ε4 allele carriers

A. Carriers: Overall P-value = 0.031, OR = 0.56 (95 % CI 0.00–0.94)
Ethnicity Phenotype Ref-Ref Alt-* P-value Odds Ratio
European Controls 137 141 0.25 0.49
AD/dementia 6 3
African Controls 68 145 0.19 0.54
AD/dementia 7 8
Hispanic Controls 155 146 0.12 0.56
AD/dementia 17 9
B. Non-Carriers: Overall P-value = 0.060, OR = 0.77 (95 % CI 0.00–1.01)
Ethnicity Phenotype Ref-Ref Alt-* P-value Odds Ratio
European Controls 588 637 0.43 0.83
AD/dementia 10 9
African Control 233 453 0.24 0.74
AD/dementia 14 20
Hispanic Control 867 731 0.17 0.80
AD/dementia 62 42