Fig. 4

Identification and characterization of DhMRs in AD mouse model. a Compared to age-matched WT mice, 5324 and 4975 DhMRs were identified from adult and aged DTg-specific mice, respectively. 244 specific DhMRs were shared between adult and aged DTg mice, which did not exist either in adult or aged WT mice. b The distribution features of DhMRs identified in adult and aged DTg mice, respectively. DhMRs highly enrich in introns, exons and intergenic regions. Pearson’s Chi-squared test with Yates’ continuity correction was performed using their absolute mapped reads inside and outside of each genomic feature. P-values for these tests were significant (<2.2e-16). c KEGG assay shows DhMR-associated genes are significantly enriched in multiple neuronal signaling pathways. d KEGG assay indicates aged mice specific DhMRs-associated genes are also significantly enriched in multiple pathways, including Alzheimer’s disease